Table 1

Disease burden model parameter values, with references, for susceptible and resistant E. coli urinary tract infections in the Netherlands and the Italy settings, as derived from systematic review

ParameterNetherlandsItaly
SusceptibleResistantSusceptibleResistant
P(Bact|UTI)3.6% (95% CI 3.4% to 3.8%)39*3.6% (95% CI 3.4% to 3.8%)39*3.6% (95% CI 3.4% to 3.8%)*3.6% (95% CI 3.4% to 3.8%)*
P(Death|Bact)11.3% (24/212)2927.5% (19/69)295.47%†26.2%40
P(PTSD|Bact)Uniform(0.13, 0.21)14Uniform(0.13, 0.21)14Uniform(0.13, 0.21)14Uniform(0.13, 0.21)14
P(CogImp|Bact)Uniform(0.11–0.47)14Uniform(0.11–0.47)14Uniform(0.11–0.47)14Uniform(0.11–0.47)14
P(PhysImp|Bact)1.0141.0141.0141.014
P(Renal|Bact)Uniform(0.009–0.13)14Uniform(0.009–0.13)14Uniform(0.009–0.13)14Uniform(0.009–0.13)14
DD(UTI)5.1d (95% CI 4.3 to 5.9)418.7d (95%CI 7.0 to 10.8)4110d (IQR (7–17))42 4310d (IQR (7–17)42 43
DD(Bact)2.9d (95% CI 1.7 to 4.0)447.9d (95% CI 3.5 to 13.0)4413±94520±17 days45
DW(UTI)Uniform(0.039, 0.152)14Uniform(0.039, 0.152)14Uniform(0.039, 0.152)14Uniform(0.039, 0.152)14
DW(Bact)Pert(0.579,0.655,0.727)14Pert(0.579,0.655,0.727)14Pert(0.579,0.655,0.727)14Pert(0.579,0.655,0.727)14
DW(PTSD)Pert(0.07,0.808,0.108)14Pert(0.07,0.808,0.108)14Pert(0.07,0.808,0.108)14Pert(0.07,0.808,0.108)14
DW(CogImp)Pert(0.026,0.043,0.064)14Pert(0.026,0.043,0.064)14Pert(0.026,0.043,0.064)14Pert(0.026,0.043,0.064)14
DW(PhysImp)Uniform(0.011,0.053)14Uniform(0.011,0.053)14Uniform(0.011,0.053)14Uniform(0.011,0.053)14
DW(Renal)Uniform(0.03,0.487)14Uniform(0.03,0.487)14Uniform(0.03,0.487)14Uniform(0.03,0.487)14

  • *Pooled value from Mangen et al.5

  • †Calculated using the mortality rate of resistant E. coli bacteraemia given in Palacios-Baena et al40 and the ratio between resistant E. coli bacteraemia mortality and E.coli bacteraemia mortality in Tumbarello et al.45

  • CI, confidence interval.