Disease burden model parameter values, with references, for susceptible and resistant E. coli urinary tract infections in the Netherlands and the Italy settings, as derived from systematic review
Parameter | Netherlands | Italy | ||
Susceptible | Resistant | Susceptible | Resistant | |
P(Bact|UTI) | 3.6% (95% CI 3.4% to 3.8%)39* | 3.6% (95% CI 3.4% to 3.8%)39* | 3.6% (95% CI 3.4% to 3.8%)* | 3.6% (95% CI 3.4% to 3.8%)* |
P(Death|Bact) | 11.3% (24/212)29 | 27.5% (19/69)29 | 5.47%† | 26.2%40 |
P(PTSD|Bact) | Uniform(0.13, 0.21)14 | Uniform(0.13, 0.21)14 | Uniform(0.13, 0.21)14 | Uniform(0.13, 0.21)14 |
P(CogImp|Bact) | Uniform(0.11–0.47)14 | Uniform(0.11–0.47)14 | Uniform(0.11–0.47)14 | Uniform(0.11–0.47)14 |
P(PhysImp|Bact) | 1.014 | 1.014 | 1.014 | 1.014 |
P(Renal|Bact) | Uniform(0.009–0.13)14 | Uniform(0.009–0.13)14 | Uniform(0.009–0.13)14 | Uniform(0.009–0.13)14 |
DD(UTI) | 5.1d (95% CI 4.3 to 5.9)41 | 8.7d (95%CI 7.0 to 10.8)41 | 10d (IQR (7–17))42 43 | 10d (IQR (7–17)42 43 |
DD(Bact) | 2.9d (95% CI 1.7 to 4.0)44 | 7.9d (95% CI 3.5 to 13.0)44 | 13±945 | 20±17 days45 |
DW(UTI) | Uniform(0.039, 0.152)14 | Uniform(0.039, 0.152)14 | Uniform(0.039, 0.152)14 | Uniform(0.039, 0.152)14 |
DW(Bact) | Pert(0.579,0.655,0.727)14 | Pert(0.579,0.655,0.727)14 | Pert(0.579,0.655,0.727)14 | Pert(0.579,0.655,0.727)14 |
DW(PTSD) | Pert(0.07,0.808,0.108)14 | Pert(0.07,0.808,0.108)14 | Pert(0.07,0.808,0.108)14 | Pert(0.07,0.808,0.108)14 |
DW(CogImp) | Pert(0.026,0.043,0.064)14 | Pert(0.026,0.043,0.064)14 | Pert(0.026,0.043,0.064)14 | Pert(0.026,0.043,0.064)14 |
DW(PhysImp) | Uniform(0.011,0.053)14 | Uniform(0.011,0.053)14 | Uniform(0.011,0.053)14 | Uniform(0.011,0.053)14 |
DW(Renal) | Uniform(0.03,0.487)14 | Uniform(0.03,0.487)14 | Uniform(0.03,0.487)14 | Uniform(0.03,0.487)14 |
*Pooled value from Mangen et al.5
†Calculated using the mortality rate of resistant E. coli bacteraemia given in Palacios-Baena et al40 and the ratio between resistant E. coli bacteraemia mortality and E.coli bacteraemia mortality in Tumbarello et al.45
CI, confidence interval.