Table 1

SPIRIT flow diagram: schedule of enrolment, interventions and assessments

Timepoint	Enrolment allocation		During the operation		Postoperative follow-up−
Timepoint	−D1	D1	D01	D02	PACU	2 hours	4 hours	12 hours	24 hours	48 hours
Enrolment
Patient screening	√
Informed consent	√
Allocation		√
Random assignment		√
Intervention:
SF group				√
OCA group				√
OCB group				√
OCC group				√
Assessments:
Eligibility criteria		√
Baseline data		√
Vital signs		√
TPVB and assessment			√
NRS score					√	√	√	√	√	√
Ramsay score					√	√	√	√	√	√
Additional analgesic medication					√	√	√	√	√	√
Consumption of sufentanil or oxycodone					√	√	√	√	√	√
Number of manual compressions					√	√	√	√	√	√
Occurrence of adverse reactions:						√	√	√	√	√
PONV						√	√	√	√	√
Respiratory depression						√	√	√	√	√
Pruritus						√	√	√	√	√

−D1, the day before surgery; D01, day of surgery, before the start of the operation; D02, 20 min before the end of the surgery.
NRS, Numerical Rating Scale; PACU, postanaesthesia care unit; PONV, postoperative nausea and vomiting; SPIRIT, Standard Protocol Items: Recommendations for Interventional Trials; TPVB, thoracic paravertebral nerve block.