Framing of this systematic review with key items identified by the CHARMS checklist32
| Items | Comments |
| Prognostic vs diagnostic prediction model | Prognostic prediction model (aimed to predict future survival outcomes of people diagnosed with OPSCC) |
| Intended scope of the review | Prognostic prediction models to inform clinicians’ therapeutic decision-making regarding the management of OPSCC |
| Type of prediction modelling studies | All study types including prognostic prediction modelling studies (with or without external validation) and external model validation studies (with or without model updating) |
| Target population to whom the prediction model applies | Patients diagnosed with OPSCC according to criteria in each eligible study included in the review |
| Outcome to be predicted | Future survival outcomes after diagnosis of OPSCC, including overall survival (and/or disease-related mortality), progression-free survival and disease-free survival |
| Time span of prediction | Survival outcomes occurring at any time point after diagnosis of OPSCC |
| Intended moment of using the model | At any time point after diagnosis of OPSCC |
CHARMS, critical appraisal and data extraction for systematic reviews of prediction modelling; OPSCC, oropharyngeal squamous cell carcinoma.