HR estimated in Cox model based on cardiovascular outcomes by endophenotypes
| Variables | Female | Male | All |
| CVD event | |||
| Endophenotype 1 (reference group) | 1 | 1 | 1 |
| Endophenotype 2 | 4.9 (1.6 to 15.4) | 4.2 (2.6 to 6.6) | 6.6 (4.0 to 9.3) |
| Endophenotype 3 | 2.2 (1.1 to 4.5) | 1.4 (0.9 to 2.4) | 1.4 (0.9 to 2.1) |
| Endophenotype 4 | 8.7 (4.5 to 16.8) | 3.9 (2.7 to 5.8) | 5.7 (4.1 to 8.0) |
| Endophenotype 5 | 14.7 (6.7 to 32.0) | 9.1 (6.0 to 13.6) | 13.2 (9.2 to 18.9) |
| Endophenotype 6 | 51.8 (27.4 to 98.0) | 19.6 (13.5 to 28.5) | 30.3 (21.9 to 41.8) |
| Endophenotype 7 | 19.0 (10.0 to 36.1) | 11.5 (7.6 to 17.5) | 12.1 (8.6 to 17.1) |
| Endophenotype 8 | 54.0 (29.7 to 98.2) | 18.7 (13.1 to 26.7) | 27.4 (20.2 to 37.0) |
| Hard CVD | |||
| Endophenotype 1 (reference group) | 1 | 1 | 1 |
| Endophenotype 2 | 6.7 (1.2 to 36.4) | 3.6 (1.4 to 9.0) | 5.3 (2.4 to 11.9) |
| Endophenotype 3 | 0.98 (0.2 to 3.9) | 2.7 (1.2 to 6.4) | 1.6 (0.8 to 3.3) |
| Endophenotype 4 | 5.0 (1.5 to 16.2) | 6.5 (3.2 to 13.2) | 7.4 (4.1 to 13.5) |
| Endophenotype 5 | 13.2 (3.5 to 49.2) | 16.7 (8.1 to 34.3) | 21.4 (11.6 to 39.5) |
| Endophenotype 6 | 72.5 (25.8 to 203.5) | 37.9 (19.2 to 75.1) | 53.9 (30.5 to 95.3) |
| Endophenotype 7 | 13.5 (4.5 to 40.3) | 19.1 (9.2 to 39.8) | 15.1 (8.2 to 27.8) |
| Endophenotype 8 | 59.6 (22.1 to 160.2) | 32.1 (16.5 to 62.5) | 40.5 (23.3 to 70.2) |
| CVD mortality | |||
| Endophenotype 1 (reference group) | – | 1 | 1 |
| Endophenotype 2 | – | 4.4 (1.2 to 16.4) | 6.3 (1.8 to 21.6) |
| Endophenotype 3 | – | 2.4 (0.6 to 8.8) | 1.5 (0.4 to 4.8) |
| Endophenotype 4 | – | 3.9 (1.3 to 12.0) | 5.4 (2.0 to 14.6) |
| Endophenotype 5 | – | 16.1 (5.5 to 47.2) | 22.5 (8.5 to 60.1) |
| Endophenotype 6 | – | 43.1 (15.6 to 119.0) | 78.4 (31.8 to 193.5) |
| Endophenotype 7 | – | 22.8 (7.8 to 67.0) | 17.5 (6.6 to 46.0) |
| Endophenotype 8 | – | 32.7 (12.1 to 88.5) | 44.4 (18.3 to 107.9) |
All comparison were statistically significant except endophenotype 3 (p<0.05).
Values are presented as HR (95% CI).
CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio.