Association between cardiometabolic phenotype and quartiles of DIL and DIL Scores of AZAR cohort population
| Quartiles of DIL | Quartiles of DII | |||||||
| 1 (n=3711) | 2 (n=3730) | 3 (n=3725) | 4 (3726) | 1 (n=3708) | 2 (n=3726) | 3 (n=3730) | 4 (3728) | |
| Q rang | ≤99 828.05 | 99 828.06–129348.53 | 129 348.54–171278.60 | >171 278.61 | ≤44.43 | 44.44–48.64 | 48.65–55.29 | >55.30 |
| Crude | ||||||||
| MUHN | Reference | 0.54 (0.38–0.75) | 0.32 (0.22–0.47) | 0.21 (0.14–0.32) | Reference | 0.47 (0.33–0.66) | 0.46 (0.32–0.64) | 0.18 (0.11–0.28) |
| MHO | Reference | 0.95 (0.83–1.08) | 0.83 (0.73–0.95) | 0.76 (0.67–0.86) | Reference | 0.91 (0.80–1.04) | 0.92 (0.81–1.04) | 0.77 (0.68–0.88) |
| MUHO | Reference | 0.65 (0.57–0.75) | 0.50 (0.44–0.57) | 0.37 (0.33–0.43) | Reference | 0.68 (0.59–0.77) | 0.53 (0.47–0.61) | 0.39 (0.34–0.45) |
| MUHN | ||||||||
| Model 1 | Reference | 0.66 (0.46–0.93) | 0.45 (0.30–0.67) | 0.34 (0.22–0.53) | Reference | 0.59 (0.410.84) | 0.58 (0.41–0.83) | 0.24 (0.15–0.37) |
| Model2 | Reference | 061 (0.42–0.90) | 0.38 (0.23–0.62) | 0.23 (0.12–0.47) | Reference | 0.57 (0.40–0.81) | 0.57 (0.40–0.82) | 0.24 (0.15–0.37) |
| MHO | ||||||||
| Model1 | Reference | 1.05 (0.91–1.20) | 1.03 (0.90–1.18) | 1.04 (0.90–1.20) | Reference | 0.97 (0.85–1.11) | 1.03 (0.90–1.17) | 0.88 (0.78–1.01) |
| Model2 | Reference | 1.01 (0.87–1.16) | 0.94 (0.80–1.09) | 0.85 (0.74–1.04) | Reference | 0.91 (0.80–1.04) | 0.94 (0.82–1.07) | 0.80 (0.70–0.91) |
| MUHO | ||||||||
| Model1 | Reference | 0.88 (0.76–1.01) | 0.85 (0.74–0.99) | 0.80 (0.69–0.93) | Reference | 0.86 (0.75–0.99) | 0.74 (0.64–0.85) | 0.57 (0.50–0.66) |
| Model2 | Reference | 0.48 (0.38–0.59) | 0.65 (0.55–0.76) | 0.772 (0.66–0.89) | Reference | 0.77 (0.67–0.89) | 0.64 (0.56–0.74) | 0.48 (0.42–0.561) |
| Male | ||||||||
| Crude | ||||||||
| MUHN | Reference | 0.54 (0.30–0.97) | 0.40 (0.23–0.71) | 0.24 (0.13–0.43) | Reference | 0.57 (0.33–0.99) | 0.45 (0.26–0.77) | 0.25 (0.14–0.46) |
| MHO | Reference | 1.17 (0.92–1.48) | 1.18 (0.94–1.48) | 1.24 (1.00–1.54) | Reference | 1.02 (0.83–1.24) | 1.06 (0.87–1.28) | 0.90 (0.75–1.09) |
| MUHO | Reference | 0.66 (0.52–0.83) | 0.70 (0.55–0.90) | 0.78 (0.60–1.01) | Reference | 0.86 (0.70–1.07) | 0.65 (0.53–0.80) | 0.52 (0.42–0.64) |
| MUHN | ||||||||
| Model 1 | Reference | 0.56 (0.31–1.02) | 0.44 (0.25–0.79) | 0.28 (0.15–0.52) | Reference | 0.64 (0.37–1.11) | 0.46 (0.27(0.80) | 0.27 (0.15–0.50) |
| Model2 | Reference | 0.49 (0.26–0.92) | 0.34 (0.17–0.69) | 0.17 (0.06–0.46) | Reference | 0.66 (0.38–1.14) | 0.50 (0.29–0.86) | 0.30 (0.16–0.55) |
| MHO | ||||||||
| Model1 | Reference | 1.12 (0.88–1.42) | 1.10 (0.88–1.39) | 1.16 (0.93–1.45) | Reference | 0.99 (0.81–1.21) | 1.01 (0.84–1.22) | 0.86 (0.71–1.03) |
| Model2 | Reference | 1.05 (0.82–1.35) | 0.98 (0.76–1.26) | 0.93 (0.70–1.24) | Reference | 0.98 (0.80–1.19) | 0.99 (0.81–1.20) | 0.82 (0.68–1) |
| MUHO | ||||||||
| Model1 | Reference | 0.78 (0.60–1.01) | 0.72 (0.56–0.92) | 0.70 (0.55–0.89) | Reference | 0.89 (0.72–1.11) | 0.65 (0.53–0.81) | 0.53 (0.43–0.65) |
| Model2 | Reference | 0.68 (0.52–0.89) | 0.55 (0.42–0.73) | 0.41 (0.30–0.57) | Reference | 0.89 (0.71–1.11) | 0.64 (0.52–0.80) | 0.51 (0.41–0.63) |
| Female | ||||||||
| Crude | ||||||||
| MUHN | Reference | 0.60 (0.39–0.92) | 0.31 (0.17–0.56) | 0.29 (0.14–0.60) | Reference | 0.45 (0.28–0.72) | 0.62((0.39–0.98) | 0.15 (0.07–0.32) |
| MHO | Reference | 1.09 (0.92–1.29) | 1.08 (0.90–1.30) | 0.95 (0.77–1.18) | Reference | 0.98 (0.82–1.17) | 1.09 (0.91–1.32) | 0.97 (0.80–1.17) |
| MUHO | Reference | 0.80 (0.68–0.95) | 0.77 (0.64–0.93) | 0.62 (0.50–0.77) | Reference | 0.74 (0.62–0.89) | 0.72 (0.60–0.87) | 0.55 (0.45–0.66) |
| MUHN | ||||||||
| Model 1 | Reference | 0.77 (0.50–1.18) | 0.43 (0.23–0.78) | 0.42 (0.20–0.88) | Reference | 0.55 (0.34–0.89) | 0.78 (0.49–1.25) | 0.18 (0.08–0.39) |
| Model2 | Reference | 0.66 (0.40–1.10) | 0.33 (0.15–0.70) | 0.29 (0.11–0.78) | Reference | 0.57 (0.35–0.92) | 0.82 (0.51–1.31) | 0.19 (0.09–0.41) |
| MHO | ||||||||
| Model1 | Reference | 1.06 (0.90–1.26) | 1.06 (0.88–1.28) | 0.95 (0.6–1.17) | Reference | 0.96 (0.808–1.15) | 1.07 (0.89–1.30) | 0.95 (0.78–1.14) |
| Model2 | Reference | 0.98 (0.81–1.19) | 0.92 (0.73–1.18) | 0.77 (0.57–1.05) | Reference | 0.95 (0.8–1.14) | 1.06 (0.88–1.29) | 0.93 (0.77–1.13) |
| MUHO | ||||||||
| Model1 | Reference | 0.95 (0.80–1.13) | 0.96 (0.79–1.17) | 0.81 (0.64–1.01) | Reference | 0.84 (0.70–1.01) | 0.84 (0.69–1.02) | 0.62 (0.51–0.76) |
| Model2 | Reference | 0.78 (0.64–0.95) | 0.67 (0.52–0.86) | 0.47 (0.34–0.66) | Reference | 0.83 (0.69–1.00) | 0.83 (0.68–1.01) | 0.60 (0.49–0.74) |
Metabolically Healthy Lean (MHL) was considered as a reference group; Model 1: adjusted for age, gender, education level, WSI; Model 2 adjusted for age, gender, MET, energy intake. Adjusted for gender where appropriate.
DII, Dietary Insulin Index; DIL, dietary insulin load; MET, metabolic equivalent of task; MHO, Metabolically Healthy Obese; MUHN, Metabolically Unhealthy Normal Weight; MUHO, Metabolically Unhealthy Obese; WSI, Wealth Score Index.