Plasma pharmacokinetics (PK) sampling scheme
| Plasma PK sampling study day | Time window | Predose ≤30 min | 30 min ±5 min | 1 hour ±5 min | 90 min ±15 min | 2 hours ±15 min |
| Day 1 | Start of infusion 1 (t=0 hour) | x | x | x | ||
| Day 2 | Start of infusion 4 (t=24 hours) | x | x | x | ||
| Day 3 | Start of infusion 5 (t=48 hours) | x | x | x |