PEO framework for systematic review search
| PEO framework | |
| Population | Transgender women, transfeminine, gender-diverse and/or non-binary individuals |
| Exposure of Interest | Serum oestradiol levels resulting from GAOT use |
| Outcome | 1°: incidence of adverse cardiovascular events (e.g., MI) |
| 2°: incidence of cardiovascular-related mortality | |
| 3°: changes in cardiovascular risk factors (e.g., blood pressure) |
GAOT, gender-affirming oestrogen therapy; MI, myocardial infarction ; PEO, population, exposure of interest, outcome.