Model validation results on CVC sample compared with PTP and CAD2 score: diagnostic decisions comparison
| MPA model ESC adjusted >5% | PTP score >15% | CAD2 score >15% | |
| AuROC | 0.87 | 0.80 | 0.82 |
| AuROC 95% CI | 0.84 to 0.91 | 0.76 to 0.85 | 0.79 to 0.85 |
| Sensitivity | 82.3% | 87.6% | 88.5% |
| Specificity | 77.4% | 45.6% | 50.8% |
| PPV | 41.3% | 23.8% | 25.8% |
| NPV | 95.8% | 95.0% | 95.8% |
| FPR | 22.6% | 54.4% | 49.2% |
| FNR | 17.7% | 12.4% | 11.5% |
AuROC, area under the ROC curve; CAD2, Coronary Artery Disease consortium clinical; CVC, cardiovascular clinic; ESC, European Society of Cardiology; FNR, false negative ratio; FPR, false positive ratio; MPA, memetic pattern-based algorithm; NPV, negative predictive value; PPV, positive predictive value; PTP, pretest probability; ROC, receiver operating characteristic.