Table 3

Maximum acceptable decrease in the probability of achieving clear or almost clear skin at week 16

Attribute/levelMaximum acceptable decrease in the probability of achieving clear or almost clear skin (95% CI)
Itch reduction
2 out of 10 (20%)Reference
4 out of 10 (40%)38.7 (28.8 to 48.6)
5 out of 10 (50%)50.1 (38.5 to 61.8)
Eye inflammation
20 out of 100 (20%)Reference
10 out of 100 (10%)17.9 (10.5 to 25.4)
0 out of 100 (0%)42.3 (30.0 to 54.5)
Serious infections
6 out of 100 (6%)Reference
3 out of 100 (3%)20.6 (12.7 to 28.6)
0 out of 100 (0%)48.6 (35.2 to 62.0)
Speed of onset
2 weeksReference
1 week0.2 (−6.5 to 6.9)
2 days11.3 (4.4 to 18.2)
Flare management
NoReference
Yes5.8 (0.5 to 11.1)
Long-term disease management
Yes, without the possibility for pausesReference
Should not be used long-term4.3 (−2.7 to 11.3)
Yes, with the possibility for pauses24.1 (16.5 to 31.6)
Administration
Injection under the skin every 2 weeksReference
Oral pill one time or two times per day16.6 (9.2 to 24.0)
Check-ups
Frequent check-ups requiredReference
Occasional check-ups required16.1 (8.7 to 23.5)
No check-ups required20.9 (12.3 to 29.5)