The time course for data collection and follow-up
| Study period | Enrolment and allocation | Follow-up | |||||
| Time point | Screening (−14~0 day) | Allocation (0 day) | 7 days (±3 days) | 1 month (±7 days) | 3 months (±15 days) | 6 months (±30 days) | 12 months (±30 days) |
| Informed consent | X | ||||||
| Demographics | X | ||||||
| Allocation | X | ||||||
| Vital signs | X | X | X | X | X | X | |
| Previous medical history | X | ||||||
| Inclusion/exclusion assessment | X | ||||||
| Routine blood | X | X | |||||
| Blood biochemistry | X | X | |||||
| Pregnancy check | X | ||||||
| Blood coagulation function | X | ||||||
| D-dimer | X | ||||||
| ECG | X | ||||||
| Doppler ultrasonography of lower extremity vein | X | X | X | X | X | X | |
| VCSS | X | X | X | X | X | ||
| AVVQ | X | X | X | X | X | ||
| Instrument performance evaluation | X | ||||||
| Drug use | X | X | X | X | X | X | X |
| Adverse events | X | X | X | X | X | X | X |
AVVQ, Aberdeen Varicose Vein Questionnaire; VCSS, Venous Clinical Severity Score.