Table 2

Univariate and multivariable Cox proportional hazards models of anorectal melanoma-specific survival

Clinical parametersUnivariate analysisMultivariable analysis
HR (95% CI)P valueHR (95% CI)P value
Age at diagnosis
 <78Reference1
 ≥781.25 (1.01 to 1.55)0.0391.41 (1.12 to 1.78)0.004
Sex
 MaleReference1
 Female1.07 (0.88 to 1.30)0.4870.97 (0.80 to 1.19)0.799
Race
 White AmericanReference
 Black American1.18 (0.82 to 1.71)0.374
 Asian American0.98 (0.73 to 1.33)0.918
Marital status
 MarriedReference
 Never married1.05 (0.76 to 1.44)0.782
 Previously married1.16 (0.93 to 1.43)0.181
 Unknown1.10 (0.65 to 1.86)0.714
Location
 RectalReferenceReference
 Anorectal junction0.83 (0.65 to 1.06)0.1380.92 (0.71 to 1.89)0.506
 Anal0.73 (0.58 to 0.90)0.0040.81 (0.65 to 1.01)0.049
Stage
 LocalisedReferenceReference
 Regional1.43 (1.12 to 1.86)0.0061.43 (1.07 to 1.91)0.017
 Distant3.57 (2.80 to 4.45)<0.0013.37 (2.56 to 4.42)<0.001
 Unknown1.60 (1.11 to 2.29)0.0111.49 (1.03 to 2.17)0.036
Positive lymph nodes, number
 0ReferenceReference
 ≥12.58 (1.75 to 3.79)<0.0011.71 (1.14 to 2.57)0.010
 No examination2.13 (1.50 to 3.01)<0.0011.57 (1.09 to 2.56)0.015
 Unknown1.69 (1.01 to 2.83)0.0451.17 (0.69 to 1.99)0.557
Chemotherapy
 YesReferenceReference
 No or unknown0.64 (0.52 to 0.81)<0.0011.00 (0.78 to 1.29)0.994
  • Bold p values denote statistical significance at the p≤0.05