Univariate and multivariable Cox proportional hazards models of anorectal melanoma-specific survival
| Clinical parameters | Univariate analysis | Multivariable analysis | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age at diagnosis | ||||
| <78 | Reference | 1 | ||
| ≥78 | 1.25 (1.01 to 1.55) | 0.039 | 1.41 (1.12 to 1.78) | 0.004 |
| Sex | ||||
| Male | Reference | 1 | ||
| Female | 1.07 (0.88 to 1.30) | 0.487 | 0.97 (0.80 to 1.19) | 0.799 |
| Race | ||||
| White American | Reference | – | ||
| Black American | 1.18 (0.82 to 1.71) | 0.374 | – | – |
| Asian American | 0.98 (0.73 to 1.33) | 0.918 | – | – |
| Marital status | ||||
| Married | Reference | – | ||
| Never married | 1.05 (0.76 to 1.44) | 0.782 | – | – |
| Previously married | 1.16 (0.93 to 1.43) | 0.181 | – | – |
| Unknown | 1.10 (0.65 to 1.86) | 0.714 | – | – |
| Location | ||||
| Rectal | Reference | Reference | ||
| Anorectal junction | 0.83 (0.65 to 1.06) | 0.138 | 0.92 (0.71 to 1.89) | 0.506 |
| Anal | 0.73 (0.58 to 0.90) | 0.004 | 0.81 (0.65 to 1.01) | 0.049 |
| Stage | ||||
| Localised | Reference | Reference | ||
| Regional | 1.43 (1.12 to 1.86) | 0.006 | 1.43 (1.07 to 1.91) | 0.017 |
| Distant | 3.57 (2.80 to 4.45) | <0.001 | 3.37 (2.56 to 4.42) | <0.001 |
| Unknown | 1.60 (1.11 to 2.29) | 0.011 | 1.49 (1.03 to 2.17) | 0.036 |
| Positive lymph nodes, number | ||||
| 0 | Reference | Reference | ||
| ≥1 | 2.58 (1.75 to 3.79) | <0.001 | 1.71 (1.14 to 2.57) | 0.010 |
| No examination | 2.13 (1.50 to 3.01) | <0.001 | 1.57 (1.09 to 2.56) | 0.015 |
| Unknown | 1.69 (1.01 to 2.83) | 0.045 | 1.17 (0.69 to 1.99) | 0.557 |
| Chemotherapy | ||||
| Yes | Reference | Reference | ||
| No or unknown | 0.64 (0.52 to 0.81) | <0.001 | 1.00 (0.78 to 1.29) | 0.994 |
Bold p values denote statistical significance at the p≤0.05