Summary of UK Biobank participants with GP-prescribed clopidogrel
| CYP2C19 genotype | ||
| Normal metaboliser (*1/*1) | Intermediate/poor (any *2-*8) | |
| No of participants (% of total n=7483) | 5338 (71.3) | 2145 (28.7) |
| Females, n (% of genotype group) | 1847 (34.6) | 712 (33.2) |
| Age at first clopidogrel prescription | ||
| Minimum : maximum | 36.5 to 78.8 | 37.6 to 78.1 |
| Mean (SD) | 64.1 (7.3) | 64.3 (7.2) |
| Diagnoses* prior to clopidogrel prescription, n (%) | ||
| Ischaemic stroke | 509 (9.5) | 240 (11.2) |
| Transient ischaemic attack | 1142 (21.4) | 422 (19.7) |
| Myocardial infarction/angina | 2980 (55.8) | 1267 (59.1) |
| Atrial fibrillation | 408 (7.6) | 180 (8.4) |
| Hypertension | 3072 (57.6) | 1277 (59.5) |
| Peripheral vascular disease | 442 (8.3) | 177 (8.3) |
| Any of the above six diagnoses | 4863 (91.1) | 1982 (92.4) |
| No of clopidogrel prescriptions | ||
| Minimum : maximum | 2 to 467.0 | 2 to 494.0 |
| Mean (SD) | 28.3 (36.7) | 27.9 (36.9) |
| Years between first and last clopidogrel prescription | ||
| Minimum : maximum | 0.2 to 17.9 | 0.2 to 17.3 |
| Mean (SD) | 2.6 (3.0) | 2.5 (2.9) |
| Also prescribed aspirin while taking clopidogrel, n (%) | 2632 (49.3) | 1119 (52.2) |
| Ischaemic stroke while taking clopidogrel, n (%) | 69 (1.3) | 41 (1.9) |
| Myocardial infarction while taking clopidogrel, n (%) | 1268 (24.1) | 554 (26.4) |
Analysis of European-ancestry participants with >1 clopidogrel prescription in the available GP prescribing data. Participants excluded if clopidogrel prescribing frequency was less than once every 2 months. Events occurring after the last known date of clopidogrel prescription are also excluded.
*Ischaemic stroke diagnoses are from hospital in-patient records only; all other disease also include diagnoses recorded in primary care.
GP, general practitioner.