Comparison of the BLOCK COPD and PACE in COPD trial eligibility criteria
| BLOCK COPD trial (18) | PACE in COPD trial |
| Inclusion | |
| 40–85 years old | 40–85 years old |
| FEV1<80% predicted postbronchodilator | FEV1 ≥30% and ≤70% predicted postbronchodilator |
| FEV1/FVC ratio <0.7 postbronchodilator | FEV1/FVC ratio <0.7 postbronchodilator |
| Antibiotic/systemic glucocorticoids OR Emergency Department (ED)/hospitalisation OR prescription/or use of supplemental oxygen in previous 12 months | Have had a COPD exacerbation in the previous 24 months requiring oral corticosteroids, antibiotics or both |
| HR 65–120 bpm | HR ≥60 bpm |
| SBP >100 mm Hg | SBP ≥100 mm Hg |
| Baseline FEV1 must not fall ≥12% and ≥200 mL at 2 hours after a test dose of 1.25 mg bisoprolol, and participant must have SBP ≥100 mm Hg at 1-hour and 2-hour post-test dose. | |
| Exclusion | |
| Proven indication for use of a β-blocker, including history of myocardial infarction or revascularisation within 36 months or heart failure with a left ventricular ejection fraction <40% | Unstable left heart failure, clinically significant pulmonary hypertension, severe end-stage peripheral vascular disease, second or third-degree heart block |
| Currently using or have been prescribed long-term oxygen therapy, or resting saturated oxygen level <90% when stable | |
BLOCK COPD, Beta-Blockers for the Prevention of Acute Exacerbations of COPD; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; PACE, preventing adverse cardiac events; SBP, systolic blood pressure.