Table 3

Multivariate analysis of variables correlated with various clinical endpoints

End-point	Factors	HR	95% CI	P value
DFS	Age (＜50 years vs ≥50 years)	1.013	1.002 to 1.024	0.018
	T stage (T1–2 vs T3–4)	1.040	0.882 to 1.227	0.642
	N stage (N0–1 vs N2–3)	1.490	1.134 to 1.958	0.004
	Clinical stage (Ⅰ–Ⅱ vs Ⅲ–Ⅳb)	1.031	1.017 to 1.045	0.000
	Histology (WHO Ⅱ vs WHO Ⅲ)	2.025	1.358 to 3.020	0.001
	Tumour volume (＜23 mL vs ≥23 mL)	3.025	1.277 to 7.167	0.012
	CNN (no vs yes)	1.225	0.967 to 1.553	0.093
	LDH (≤174 IU/L vs ＞174 IU/L)	1.669	1.110 to 2.921	0.014
	AC (no vs yes)	0.870	0.641 to 1.180	0.370
OS	Age (＜50 years versus ≥50 years)	1.823	1.328 to 2.502	0.000
	T stage (T1–2 vs T3–4)	1.117	0.921 to 1.355	0.260
	N stage (N0–1 vs N2-–3)	1.276	1.004 to 1.618	0.043
	Clinical stage (Ⅰ–Ⅱ vs Ⅲ–Ⅳb)	1.163	0.881 to 1.534	0.287
	Histology (WHO Ⅱ vs WHO Ⅲ)	0.690	0.504 to 0.932	0.016
	CNN (no vs yes)	2.191	1.038 to 4.625	0.040
	Anaemia (no vs yes)	0.573	0.378 to 0.868	0.009
	Concurrent chemotherapy (no vs yes)	0.810	0.617 to 1.064	0.130
	IC (no vs yes)	1.158	0.978 to 1.371	0.089
	AC (no vs yes)	1.484	0.990 to 2.222	0.056
DMFS	N stage (N0–1 vs N2–3)	2.397	1.627 to 3.531	0.000
	Clinical stage (Ⅰ–Ⅱ vs Ⅲ–Ⅳb)	1.185	0.990 to 1.419	0.064
	Histology (WHOⅡ vs WHO Ⅲ)	0.654	0.412 to 1.037	0.071
	Tumour volume(＜23 mL vs ≥23 mL)	1.113	0.931 to 1.330	0.241
	CNN (no vs yes)	1.210	1.013 to 1.444	0.036
	EBV-DNA copy number (<5000 copy/mL vs ≥5000 copy/mL)	1.183	0.965 to 1.448	0.105
	Anaemia (no vs yes)	1.116	0.881 to 1.415	0.362
	Concurrent chemotherapy (no vs yes)	0.816	0.599 to 1.111	0.197
LRFS	CNN (no vs yes)	0.930	0.521 to 1.660	0.806
LRFS	AC (no vs yes)	1.296	0.773 to 2.172	0.326
RRFS	IC (no vs yes)	0.946	0.198 to 4.519	0.944

AC, adjuvant chemotherapy; CNN, cervical nodal necrosis; DFS, disease-free survival; DMFS, distant metastasis-free survival; IC, induction chemotherapy; LDH, lactic dehydrogenase; LRFS, local relapse-free survival; OS, overall survival; RRFS, regional relapse-free survival.