SARS-CoV-2 clades are classified by The Global Initiative on Sharing All Influenza Data (GISAID) using specific non-synonymous mutations in the viral genome. Clade G is defined by the mutations D614G, C241T, C3037T and A23403G in the Spike protein; and clade GR by additional RG203KR mutations in the Nucleocapsid protein N; clade L is most closely related to the Wuhan reference strain (NC_045512.2).34 Whole genome data were available for 13/15 sequences; data for two sequences were not available at the time of analysis. Accordingly, among the 13 sequences analysed, three different clades were identified, including clades L (N=2), GR (N=4) and G (N=7). All three clades were detected in early acute infection, and clade G was additionally detected in late acute infection. *For simplicity reasons, only mutation D614G (grey background) in the Spike protein defining clade G is shown. **Additional mutations R203K and G204R in the Nucleocapsid protein N defining clade GR are also shown in grey.

ORF, open reading frame.