Schedule of sampling
| Day | 0 | 3 | 8 | 15 | 29 |
| Urine | X | X | X | X | X |
| Blood* | X | X | X | X | X |
| Skin microbiopsy | X | X | X | X | X |
| Spleen* | X | X† | |||
| Bone marrow*‡ | X | X |
*Routine samples, all other samples will be matched to routine sample where possible.
†In an unlikely event, a splenic aspiration is contraindicated on day 29, bone marrow aspirate test of cure will be conducted as per standard practice.
‡In patients who are contraindicated for splenic aspiration, a bone marrow aspirate will be taken for diagnosis and test of cure as per standard practice. These patients will be recruited to a pilot study.