A: MR acquisition parameters for Phase 1 (n=54)
| Sequence type | Slice orientation | TR (ms) | TE (ms) | Flip angle (°) | Acquisition matrix: | Reconstructed resolution (mm) | Other parameters | Acquisition duration (min:s) |
| A: MR acquisition parameters for phase 1 (n=54) | ||||||||
| 3D-T1 | Coronal | ~7 | ~2.5 | 8 | 256×256 | 0.94×0.94×1.0 | TI=650 ms | 5:03 |
| FLAIR | Axial | 9000 | 148 | 90 | 256×256 | 0.94×0.94×3.0 | TI=2250 ms | 4:50 |
| rs-fMRI | Axial | 2000 | 30 | 70 | 64×64 | 3.75×3.75×3.8 | 200 Volumes | 5:10 |
| DWI | Axial | 9000 | ~80 | 90 | 80×80 | 0.94×0.94×3.0 | b=1000 s/mm2; 31 directions | 6:01 |
| qT118 | Axial | 15 000 | ~24 | 40 | 160×160 | 1.0×1.0×4.0 | Eight echoes; B1 map included | 8:09 |
| qT2 | Coronal | 3000 | ~8 to 128 | 90 | 256×128 | 0.94×0.94×4.0 | 16 Echoes; echo spacing=8 ms | 9:48 |
| QSM19 | Axial | 30 | ~3 to 28 | 20 | 192×192 | 1.0×1.0×1.0 | Eight echoes; echo spacing=3.4 ms | 4:13 |
| pcASL | Axial | 4899 | ~11 | 111 | 512×10 | 1.88×1.88×5.0 | Post label delay=2025 ms; NEX=1 | 6:55 |
| B: MR acquisition parameters for Phase 2 (n=271) | ||||||||
| 3D-T1 | Sagittal | ~7 | ~2.5 | 8 | 256×256 | 0.94×0.94×1.0 | TI=650 ms | 5:44 |
| FLAIR | Axial | 9000 | 148 | 90 | 256×256 | 0.94×0.94×3.0 | TI=2250 ms | 4:50 |
| rs-fMRI | Axial | 2000 | 30 | 70 | 64×64 | 3.75×3.75×3.8 | 200 Volumes | 5:10 |
| DWI | Axial | 9000 | ~80 | 90 | 80×80 | 0.94×0.94×3.0 | b=1000 s/mm2; 31 directions | 6:01 |
| qT120 | Axial | 15 000 | ~24 | 40 | 160×160 | 1.0×1.0×4.0 | Eight echoes; variable TI | 5:35 |
| qT2 | Axial | 3000 | ~8 to 128 | 90 | 256×128 | 0.94×0.94×4.0 | 16 Echoes; echo spacing=8 ms | 9:48 |
| QSM19 | Axial | 30 | ~3 to 28 | 20 | 192×192 | 1.0×1.0×1.0 | Eight echoes; echo spacing=3.4 ms | 3:58 |
| pcASL | Axial | 4899 | ~11 | 111 | 512×8 | 1.79×1.79×3.5 | Post label delay=2025 ms; NEX=3 | 4:45 |
T1, spin–lattice relaxation time constant.
T2, spin–spin relaxation time constant.
TI, inversion time.
DTI, diffusion tensor imaging; DWI, diffusion-weighted imaging; FLAIR, fluid attenuated inversion recovery; IR, inversion recovery; MR, magnetic resonance; NEX, number of excitations; pcASL, pseudo-continuous arterial spin labelling; QSM, quantitative susceptibility mapping; rs-fMRI, resting state functional MRI.