Table 2

Univariate and multivariate analyses of clinical characteristics associated with symptom severity

Characteristics	Proxy-reported version n=41		P value*	OR (CI 95%)	P value†	Self-reported version n=116		P value*
	Low severity (≤1)	High severity (≥2)				Low severity (≤1)	High severity (≥2)
	n (%)	n (%)				n (%)	n (%)
Sex
Male	8 (40.0)	8 (38.1)	0.999*	–	–	27 (39.7)	17 (35.4)	0.700*
Female	12 (60.0)	13 (61.9)	0.999*	–	–	41 (60.3)	31 (64.6)	0.700*
Primary tumour
Solid	8 (42.1)	9 (45.0)	0.520**	–	–	25 (37.9)	18 (39.1)	0.889**
Haematological	2 (10.5)	0 (0.0)		–		3 (4.5)	1 (2.2)
Central nervous system	9 (47.4)	11 (55.0)		–		38 (57.6)	27 (58.7)
Time of diagnostic
<6 months	8 (40.0)	16 (80.0)	0.022*	–	–	49 (72.1)	37 (77.1)	0.668*
>6 months	12 (60.0)	4 (20.0)	0.022*	0.14 (0.03 to 0.66)	0.012	19 (27.9)	11 (22.9)	0.668*
Distant metastasis
Yes	6 (30.0)	4 (19.0)	0.484**	–	–	49 (73.1)	37 (78.7)	0.518*
No	14 (70.0)	17 (81.0)	0.484**	–	–	18 (26.9)	10 (21.3)	0.518*
Treatment performed
Chemotherapy
Yes	20 (100)	21 (100)	–	–	–	67 (98.5)	46 (95.8)	0.569**
No	0 (0.0)	0 (0.0)	–	–	–	1 (1.5)	2 (4.2)	0.569**
Radiotherapy
Yes	0 (0.0)	1 (4.8)	0.999**	–	–	9 (13.2)	5 (10.4)	0.776*
No	20 (100)	20 (95.2)	0.999**	–	–	59 (86.8)	43 (89.6)	0.776*
Surgery
Yes	10 (50.0)	4 (19.0)	0.052*	0.20 (0.04 to 0.98)	0.047	23 (33.8)	9 (18.8)	0.093*
No	10 (50.0)	17 (81.0)	0.052*	–	–	45 (66.2)	39 (81.3)	0.093*
Collection site
Inpatient clinic	1 (5.0)	4 (19.0)	0.343**	–	–	0.999*	8 (11.8)	6 (12.5)
Outpatient clinic	18 (90.0)	17 (81.0)	0.343**	–	–	0.999*	60 (88.2)	42 (87.5)
Amputation
No	19 (95.0)	21 (100)	0.488** —	–	–	60 (90.9)	46 (97.9)	0.236** —
Yes	1 (5.0)	0 (0.0)	0.488** —	–	–	6 (9.1)	1 (2.1)	0.236** —

*Univariate analysis using ^*Pearsons Chi-square and ^**Fisher exact tests. p-value<0.2.
†Multivariate logistic regression analysis. p value<0.05 Wald test.