Table 2

Univariate and multivariate analyses of clinical characteristics associated with symptom severity

CharacteristicsProxy-reported version n=41P value*OR (CI 95%)P value†Self-reported version n=116P value*
Low severity
(≤1)
High severity
(≥2)
Low severity
(≤1)
High severity
(≥2)
n (%)n (%)n (%)n (%)
Sex
 Male8 (40.0)8 (38.1)0.999*27 (39.7)17 (35.4)0.700*
 Female12 (60.0)13 (61.9)41 (60.3)31 (64.6)
Primary tumour
 Solid8 (42.1)9 (45.0)0.520**25 (37.9)18 (39.1)0.889**
 Haematological2 (10.5)0 (0.0)3 (4.5)1 (2.2)
 Central nervous system9 (47.4)11 (55.0)38 (57.6)27 (58.7)
Time of diagnostic
<6 months8 (40.0)16 (80.0)0.022*49 (72.1)37 (77.1)0.668*
 >6 months12 (60.0)4 (20.0)0.14 (0.03 to 0.66)0.01219 (27.9)11 (22.9)
Distant metastasis
 Yes6 (30.0)4 (19.0)0.484**49 (73.1)37 (78.7)0.518*
 No14 (70.0)17 (81.0)18 (26.9)10 (21.3)
Treatment performed
Chemotherapy
 Yes20 (100)21 (100)67 (98.5)46 (95.8)0.569**
 No0 (0.0)0 (0.0)1 (1.5)2 (4.2)
Radiotherapy
 Yes0 (0.0)1 (4.8)0.999**9 (13.2)5 (10.4)0.776*
 No20 (100)20 (95.2)59 (86.8)43 (89.6)
Surgery
 Yes10 (50.0)4 (19.0)0.052*0.20 (0.04 to 0.98)0.04723 (33.8)9 (18.8)0.093*
 No10 (50.0)17 (81.0)45 (66.2)39 (81.3)
Collection site
 Inpatient clinic1 (5.0)4 (19.0)0.343**0.999*8 (11.8)6 (12.5)
 Outpatient clinic18 (90.0)17 (81.0)60 (88.2)42 (87.5)
Amputation
 No19 (95.0)21 (100)0.488**

60 (90.9)46 (97.9)0.236**


 Yes1 (5.0)0 (0.0)6 (9.1)1 (2.1)
  • *Univariate analysis using *Pearsons Chi-square and **Fisher exact tests. p-value<0.2.

  • †Multivariate logistic regression analysis. p value<0.05 Wald test.