The associations between LS7 metrics and CVD-related biomarkers in men, n=2604
| hsCRP (mg/L) | D-dimer (μg/mL) | Fibrinogen (mg/dL) | Homocysteine (μmol/L) | hs-cTnT (ng/L) | NT-ProBNP (pg/mL) | IL-6* (pg/mL) | |
| Smoking | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.16 (−0.50, 0.17) | −0.17 (−0.45, 0.11) | −0.04 (−0.10, 0.02) | −0.16
(−0.25, −0.07) | −0.07 (−0.25, 0.12) | −0.52
(−0.86, −0.19) | −0.21
(−0.42, −0.005) |
| Ideal | −0.27 (−0.39, 0.15) | −0.17
(-0.27, - 0.07) | −0.05
(−0.07, −0.03) | −0.05
(−0.08, −0.02) | 0.02 (−0.04, 0.08) | −0.15
(−0.27, −0.03) | −0.19
(−0.27, −0.12) |
| Body mass index | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.50
(−0.59, −0.40) | −0.11
(−0.20, −0.03) | −0.06
(−0.08, −0.05) | −0.01 (−0.04, 0.01) | −0.17
(−0.23, −0.12) | 0.07 (−0.02, 0.17) | −0.30
(−0.36, −0.24) |
| Ideal | −0.80
(−0.92, −0.69) | −0.17
(−0.26, −0.07) | −0.08
(−0.10, −0.06) | −0.02 (−0.05, 0.01) | −0.29
(−0.35, −0.23) |
0.25
(0.14, 0.36) | −0.37
(−0.43, −0.30) |
| Physical activity | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | 0.09 (−0.04, 0.23) | −0.06 (−0.17, 0.06) | −0.002 (−0.03, 0.02) | −0.01 (−0.05, 0.02) | −0.07 (−0.14, 0.01) | 0.03 (−0.10, 0.17) | −0.02 (−0.10, 0.07) |
| Ideal | −0.03 (−0.14, 0.07) | −0.05 (−0.13, 0.04) | −0.02
(−0.04, −0.004) | −0.02
(−0.05, −0.00) | −0.07
(−0.13, −0.02) | 0.05 (−0.05, 0.15) | −0.14
(−0.20, −0.07) |
| Diet | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.11
(−0.19, −0.02) | 0.002 (−0.07, 0.07) | −0.01 (−0.03, 0.00) | −0.003 (−0.02, 0.02) | −0.02 (−0.07, 0.02) | 0.04 (−0.04, 0.12) | −0.05
(−0.10, −0.003) |
| Ideal | −0.57 (−1.25, 0.11) | −0.50 (−1.07, 0.07) | 0.01 (−0.12, 0.14) | 0.06 (−0.11, 0.24) | −0.17 (−0.54, 0.20) | 0.31 (−0.36, 0.98) | −0.14 (−0.56, 0.27) |
| Total cholesterol | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.03 (−0.17, 0.11) | 0.01 (−0.11, 0.12) | −0.04
(−0.06, −0.01) | −0.003 (−0.04, 0.03) | −0.10
(−0.18, −0.02) | −0.09 (−0.22, 0.05) | 0.08 (−0.01, 0.16) |
| Ideal | −0.01 (−0.15,0.13) | 0.05 (−0.06, 0.17) | −0.05
(−0.08, −0.03) | −0.006 (−0.04, 0.03) | −0.10
(−0.17, −0.02) |
0.19
(0.05, 0.32) |
0.17
(0.08, 0.25) |
| Blood pressure | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.10 (−0.20, 0.01) | −0.06 (−0.14, 0.03) | −0.01 (−0.03, 0.004) | −0.03
(−0.06, −0.005) | −0.12
(−0.18, −0.07) | −0.37
(−0.47, −0.27) | −0.07
(−0.13, −0.01) |
| Ideal | −0.23
(−0.34, −0.13) | −0.01 (−0.10, 0.08) | −0.03
(−0.05, −0.01) | −0.04
(−0.07, −0.02) | −0.22
(−0.27, −0.16) | −0.40
(−0.50, −0.30) | −0.09
(−0.16, −0.03) |
| Blood glucose | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | 0.07 (−0.08, 0.22) | 0.03 (−0.09, 0.16) | −0.01 (−0.04, 0.02) | 0.04 (−0.003, 0.08) | −0.23
(−0.31, −0.15) | −0.06 (−0.21, 0.09) | −0.04 (−0.14, 0.05) |
| Ideal | −0.17
(−0.30, −0.04) | 0.04 (−0.07, 0.15) | −0.03
(−0.06, −0.01) | 0.01 (−0.02, 0.05) | −0.36
(−0.43, −0.29) | 0.04 (−0.09, 0.17) | −0.15
(−0.23, −0.07) |
*For IL-6, n=2546.
CVD, cardiovascular disease;hsCRP, high-sensitivity C-reactive protein; hs-cTnT, high-sensitivity cardiac troponin T;IL-6, interleukin 6; LS7, Life’s Simple 7; NT-proBNP, N-terminal pro B-type natriuretic peptide.