The associations between LS7 metrics and CVD-related biomarkers in women, n=2775
| hsCRP (mg/L) | D-dimer (μg/mL) | Fibrinogen (mg/dL) | Homocysteine (μmol/L) | hs-cTnT (ng/L) | NT-ProBNP (pg/mL) | IL-6* (pg/mL) | |
| Smoking | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.07 (−0.51, 0.38) | 0.11 (−0.22, 0.44) | 0.03 (−0.05, 0.11) | 0.03 (−0.08, 0.14) | 0.005 (−0.17, 0.18) | 0.003 (−0.35, 0.36) | 0.03 (−0.22, 0.29) |
| Ideal | 0.02 (−0.12, 0.16) | 0.03 (−0.07, 0.13) | −0.01 (−0.03, 0.02) | −0.08
( –0.11, – 0.04) | −0.01 (−0.07, 0.04) | 0.07 (−0.04, 0.18) | −0.10
( –0.18, –0.02) |
| Body mass index | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.61
( –0.71, –0.51) | −0.17
( –0.25, –0.10) | −0.08
(–0.10, –0.07) | −0.04
( –0.07, –0.02) | −0.07
( –0.11, –0.03) | 0.06 (−0.03, 0.14) | −0.34
( –0.40, –0.29) |
| Ideal | −1.15
( –1.25, –1.04) | −0.32
( –0.40, –0.23) | −0.14
( –0.16, –0.12) | −0.06
( –0.08, –0.03) | −0.09
( –0.14, –0.05) |
0.26
(0.17, 0.35) | −0.61
( –0.67, –0.55) |
| Physical activity | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.06 (−0.19, 0.07) | 0.05 (−0.05, 0.15) | 0.01 (−0.02, 0.03) | −0.03
( –0.07, –0.00) | −0.02 (−0.07, 0.03) | 0.01 (−0.09, 0.12) | 0.01 (−0.07, 0.08) |
| Ideal | −0.16
( –0.27, –0.06) | −0.04 (−0.11, 0.04) | −0.03
( –0.05, –0.02) | −0.02 (−0.05, 0.00) | −0.05
( –0.09, –0.005) | 0.04 (−0.05, 0.12) | −0.10
( –0.16, –0.04) |
| Diet | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.16
( –0.25, –0.07) | −0.02 (−0.09, 0.04) | −0.01 (−0.02, 0.01) | −0.002 (−0.02, 0.02) | −0.01 (−0.05, 0.02) | −0.01 (−0.09, 0.06) | −0.10
( –0.15, –0.05) |
| Ideal | −0.40
(−0.74, −0.07) | −0.09 (−0.33, 0.16) | −0.02 (−0.07, 0.04) | −0.07 (−0.16, 0.01) | −0.11 (−0.24, 0.02) | −0.05 (−0.32, 0.21) |
0.24
(−0.43, −0.06) |
| Total cholesterol | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | 0.02 (−0.11, 0.14) | −0.04 (−0.13, 0.05) | −0.02 (−0.04, 0.00) | −0.0001 (−0.03, 0.03) | −0.01 (−0.06, 0.04) |
0.12
(0.02, 0.21) |
0.09
(0.02, 0.16) |
| Ideal | −0.08 (−0.21, 0.04) | −0.02 (−0.11, 0.08) | −0.06
(−0.08, −0.04) | 0.01 (−0.02, 0.04) | −0.006 (−0.04, 0.06) |
0.24
(0.14, 0.34) |
0.13
(0.06, 0.20) |
| Blood pressure | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.13
(−0.24, −0.03) | −0.05 (−0.13, 0.03) | −0.003 (−0.02, 0.02) | −0.005 (−0.03, 0.02) | −0.09
(−0.13, −0.04) | −0.28
(−0.37, −0.20) | −0.07
(−0.13, −0.01) |
| Ideal | −0.45
(−0.56, −0.35) | −0.11
(-0.19, −0.03) | −0.02
(−0.04, −0.002) | −0.04
(−0.07, −0.01) | −0.12
(−0.16, −0.08) | −0.30
(−0.39, −0.21) | −0.21
(−0.27, −0.15) |
| Blood glucose | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.04 (−0.22, 0.14) | 0.01 (−0.13, 0.14) | −0.01 (−0.04, 0.02) | 0.04 (−0.01, 0.08) | −0.16
(−0.23, −0.09) | 0.10 (−0.04, 0.25) | −0.0002 (−0.10, 0.10) |
| Ideal | −0.43
(−0.57, −0.28) | −0.03 (−0.14, 0.08) | −0.07
(−0.09, −0.04) | 0.002 (−0.03, 0.04) | −0.19
(−0.25, −0.13) |
0.29
(0.17, 0.40) | −0.28
(−0.36, −0.20) |
*For IL-6, sample size=2733.
CVD, cardiovascular disease;hsCRP, high-sensitivity C-reactive protein; hs-cTnT, high-sensitivity cardiac troponin T;IL-6, interleukin 6; LS7, Life’s Simple 7; NT-proBNP, N-terminal pro B-type natriuretic peptide.