Sample size based on different estimates of difference between groups (measured by increase in the cycle threshold value at 72 hours after inclusion) and variant estimates of SD
| Difference between groups | SD | Sample size (per group) |
| 4 | 7.5 | 56 |
| 4 | 8.2 | 68 |
| 4.5 | 7.5 | 45 |
| 4.5 | 8.2 | 53 |
| 5 | 7.5 | 37 |
| 5 | 8.2 | 44 |
| 5.5 | 7.5 | 31 |
| 5.5 | 8.2 | 37 |