Comparisons of incidence, and HR of outcome by subtypes of clinical vertebral fracture
| Variables | N | Event | Rate† | Crude HR (95% CI) | Adjusted HR‡ (95% CI) |
| Aortic dissection | |||||
| No vertebral fracture | 108 935 | 245 | 3.99 | 1(Reference) | 1(Reference) |
| Cervical spine | 9938 | 12 | 2.15 | 0.54 (0.30 to 0.96)* | 0.92 (0.51 to 1.65) |
| Thoracic | 32 205 | 95 | 5.72 | 1.44 (1.13 to 1.82)** | 1.20 (0.95 to 1.53) |
| Lumbar | 70 723 | 220 | 5.77 | 1.45 (1.21 to 1.74)*** | 1.33 (1.11 to 1.60)** |
| Sacrum and coccyx | 7523 | 6 | 1.28 | 0.32 (0.14 to 0.72)** | 1.06 (0.47 to 2.41) |
| Without SCI | 98 984 | 265 | 5.00 | 1.25 (1.05 to 1.49)* | 1.25 (1.05 to 1.48)* |
| With SCI | 13 209 | 30 | 3.75 | 0.93 (0.64 to 1.37) | 1.10 (0.75 to 1.61) |
| Congestive heart failure | |||||
| No vertebral fracture | 108 935 | 5411 | 89.6 | 1(Reference) | 1(Reference) |
| Cervical spine | 9938 | 278 | 50.4 | 0.56 (0.50 to 0.63)*** | 1.40 (1.24 to 1.58)*** |
| Thoracic | 32 205 | 2678 | 166.6 | 1.86 (1.78 to 1.95)*** | 1.43 (1.37 to 1.50)*** |
| Lumbar | 70 723 | 4986 | 134.1 | 1.50 (1.44 to 1.56)*** | 1.38 (1.33 to 1.43)*** |
| Sacrum and coccyx | 7523 | 144 | 31.0 | 0.35 (0.29 to 0.41)*** | 1.33 (1.12 to 1.57)*** |
| Without SCI | 98 984 | 6291 | 121.5 | 1.36 (1.31 to 1.41)*** | 1.34 (1.29 to 1.39)*** |
| With SCI | 13 209 | 834 | 106.5 | 1.19 (1.10 to 1.28)*** | 1.50 (1.39 to 1.61)*** |
| Pneumonia | |||||
| No vertebral fracture | 108 935 | 10 929 | 183.5 | 1(Reference) | 1(Reference) |
| Cervical spine | 9938 | 1106 | 208.4 | 1.14 (1.07 to 1.21)*** | 2.22 (2.08 to 2.36)*** |
| Thoracic | 32 205 | 5617 | 358.8 | 1.96 (1.90 to 2.02)*** | 1.59 (1.54 to 1.64)*** |
| Lumbar | 70 723 | 11 125 | 307.1 | 1.67 (1.63 to 1.72)*** | 1.56 (1.52 to 1.60)*** |
| Sacrum and coccyx | 7523 | 437 | 95.7 | 0.52 (0.47 to 0.57)*** | 1.76 (1.60 to 1.94)*** |
| Without SCI | 98 984 | 14 378 | 284.7 | 1.55 (1.51 to 1.59)*** | 1.56 (1.52 to 1.60)*** |
| With SCI | 13 209 | 2203 | 292.8 | 1.59 (1.52 to 1.67)*** | 1.91 (1.82 to 2.00)*** |
| Acute respiratory distress syndrome | |||||
| No vertebral fracture | 108 935 | 257 | 4.18 | 1(Reference) | 1(Reference) |
| Cervical spine | 9938 | 52 | 9.33 | 2.23 (1.65 to 3.00)*** | 3.42 (2.50 to 4.68)*** |
| Thoracic | 32 205 | 191 | 11.5 | 2.76 (2.29 to 3.33)*** | 2.35 (1.94 to 2.84)*** |
| Lumbar | 70 723 | 365 | 9.57 | 2.29 (1.95 to 2.69)*** | 2.11 (1.80 to 2.48)*** |
| Sacrum and coccyx | 7523 | 10 | 2.13 | 0.51 (0.27 to 0.95)* | 1.51 (0.79 to 2.87) |
| Without SCI | 98 984 | 478 | 9.02 | 2.16 (1.85 to 2.51)*** | 2.15 (1.84 to 2.50)*** |
| With SCI | 13 209 | 87 | 10.9 | 2.58 (2.03 to 3.29)*** | 2.97 (2.34 to 3.78)*** |
*p<0.05, **p<0.01, ***p<0.001.
†Rate, incidence rate, per 10,000 person-years; Crude HR: relative hazard ratio.
‡Adjusted HR: adjusted hazard ratio controlling for age, sex, comorbidities of hypertension, diabetes, hyperlipidemia, atrial fibrillation, CKD, COPD and CCI scoreICD-9-CM: Cervical spine: 805.0-805.18, 806.0-806.19; Thoracic: 805.2, 805.3, 806.2-806.39; Lumbar: 805.4, 805.5, 806.4, 806.5; Sacrum and coccyx: 805.6, 805.7, 806.6-806.79; SCI involved or Not: Without SCI: 805-805.9 & With SCI: 806-806.9.