Multivariate analyses of factors associated with prehospital delay, first ECG delay, thrombolytic therapy delay and in-hospital delay, using logistic regression with generalised estimating equations
| Prehospital delay (n=7312) | First ECG delay (n=7312) | Thrombolytic therapy delay (n=3057) | In-hospital delay (n=3057) | |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Female | 1.20 (1.05 to 1.38) | 1.03 (0.90 to 1.18) | 1.07 (0.80 to 1.43) | 0.97 (0.80 to 1.16) |
| ≥65 years old | 1.54 (1.37 to 1.73) | 1.04 (0.92 to 1.18) | 0.97 (0.77 to 1.23) | 1.11 (0.94 to 1.31) |
| Illiteracy | 1.44 (1.17 to 1.77) | 1.12 (0.92 to 1.35) | 0.86 (0.59 to 1.25) | 1.03 (0.78 to 1.35) |
| Farmer | 1.61 (1.36 to 1.90) | 1.02 (0.85 to 1.23) | 1.21 (0.90 to 1.63) | 1.03 (0.80 to 1.34) |
| Medical insurance | 1.14 (0.73 to 1.79) | 1.21 (0.88 to 1.67) | 0.69 (0.32 to 1.45) | 0.82 (0.49 to 1.38) |
| Current smoking | 1.00 (0.86 to 1.15) | 0.90 (0.74 to 1.09) | 1.07 (0.81 to 1.42) | 1.08 (0.84 to 1.39) |
| History of disease, % | ||||
| Myocardial infarction | 0.67 (0.52 to 0.87) | 1.20 (0.94 to 1.53) | 1.16 (0.70 to 1.92) | 1.19 (0.80 to 1.78) |
| Angina | 0.91 (0.78 to 1.06) | 0.82 (0.67 to 1.00) | 0.84 (0.60 to 1.17) | 0.82 (0.59 to 1.14) |
| Stroke | 1.19 (0.99 to 1.42) | 0.92 (0.74 to 1.14) | 1.30 (0.83 to 2.03) | 1.32 (0.92 to 1.88) |
| Heart failure | 1.25 (0.84 to 1.88) | 0.95 (0.64 to 1.41) | 0.74 (0.24 to 2.25) | 1.09 (0.37 to 3.22) |
| TIA | 0.68 (0.45 to 1.05) | 1.01 (0.56 to 1.82) | 1.06 (0.46 to 2.42) | 0.63 (0.31 to 1.28) |
| Diabetes | 0.98 (0.85 to 1.13) | 1.00 (0.84 to 1.18) | 1.19 (0.86 to 1.64) | 1.26 (0.94 to 1.68) |
| Hypertension | 0.89 (0.79 to 0.99) | 1.01 (0.90 to 1.14) | 1.03 (0.83 to 1.29) | 1.04 (0.89 to 1.22) |
| Dyslipidaemia | 1.04 (0.80 to 1.35) | 1.03 (0.74 to 1.43) | 0.68 (0.40 to 1.15) | 0.62 (0.40 to 0.97) |
| Time cycles (every 6 months) | 0.97 (0.91 to 1.05) | 0.87 (0.76 to 0.99) | 1.01 (0.87 to 1.17) | 0.99 (0.84 to 1.15) |
| Symptom onset time | ||||
| 00:00-05:59 | 2.04 (1.80 to 2.32) | – | – | – |
| 06:00-11:59 | 1.47 (1.28 to 1.68) | – | – | – |
| 12:00-17:59 | Ref | – | – | – |
| 18:00-23:59 | 1.00 (0.89 to 1.13) | – | – | – |
| Vital signs at admission | ||||
| SBP <90 mm Hg | 0.57 (0.46 to 0.71) | 0.78 (0.59 to 1.04) | 0.85 (0.56 to 1.28) | 0.86 (0.60 to 1.24) |
| Heart rates ≥100 beats/min | 1.71 (1.48 to 1.99) | 1.05 (0.90 to 1.23) | 1.61 (1.04 to 2.50) | 1.35 (0.94 to 1.96) |
| Arrived at regular hours | – | 1.12 (1.00 to 1.25) | 0.94 (0.77 to 1.15) | 0.81 (0.68 to 0.96) |
| Prehospital delay | – | 1.14 (0.99 to 1.32) | 0.78 (0.64 to 0.95) | 0.86 (0.73 to 1.02) |
| First ECG delay | – | – | 0.56 (0.41 to 0.78) | |
| CPACS-3 intervention* | 1.08 (0.86 to 1.36) | 0.78 (0.51 to 1.18) | 1.03 (0.65 to 1.63) | 0.73 (0.47 to 1.13) |
The results of univariate analyses of four kinds of delays are shown in online supplementary table 1.
*The intervention of the third phase of the Clinical Pathways for Acute Coronary Syndromes Study.
CPACS-3, Third phase of the Clinical Pathways for Acute Coronary Syndrome; SBP, systolic blood pressure; TIA, transient ischaemic attack.