Table 2

Association of BMI-independent leptin GRS1* with baseline lipids among overall, drinking and non-drinking participants of the FHS third generation cohort, respectively

	Age, sex, BMI, waist circumference adjusted model		P_interaction ^†	Fully adjusted model^‡		P_interaction ^§
	Beta (SE)	P value	P_interaction ^†	Beta (SE)	P value	P_interaction ^§
HDL-C
Overall	5.42 (7.10)	0.44	0.74	7.79 (7.11)	0.27	0.71
Not current drinkers	20.42 (18.29)	0.26		22.22 (18.76)	0.24
Current drinkers	6.00 (7.61)	0.43		7.02 (7.64)	0.36
LDL-C
Overall	−0.11 (16.09)	0.99	0.79	−1.09 (16.24)	0.95	0.93
Not current drinkers	3.37 (48.63)	0.94		−4.18 (50.10)	0.93
Current drinkers	−0.14 (17.10)	0.99		−1.80 (17.18)	0.92
Log-TG
Overall	−0.66 (0.26)	0.01	0.31	−0.69 (0.26)	0.008	0.32
Not current drinkers	−1.41 (0.80)	0.08		−1.32 (0.82)	0.11
Current drinkers	−0.58 (0.27)	0.04		−0.61 (0.27)	0.03
Total cholesterol
Overall	−12.50 (18.21)	0.49	0.96	−12.58 (18.31)	0.49	0.86
Not current drinkers	−15.20 (54.11)	0.78		−19.13 (55.66)	0.73
Current drinkers	−10.20 (19.37)	0.60		−11.43 (19.42)	0.56

*GRS1 for leptin was generated by summing leptin increasing alleles of three SNPs adjusted for BMI, weighted by their corresponding effect sizes reported by Kilpelainen et al.
†Assessed by adding an interaction term, drinking×GRS along with the drinking variable to the age, sex, BMI and waist circumference adjusted model among the overall participants.
‡Adjusted for age, sex, education, smoking, drinking, BMI, waist circumference and physical activity among the overall sample.
§Assessed by adding an interaction term, drinking×GRS to the fully adjusted model among the overall participants.
BMI, body mass index; FHS, Framingham Heart Study; GRS, genetic risk score; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; log-TG, logarithmically transformed triglycerides; SE, standard error; SNPs, single-nucleotide polymorphisms.