Table 3

Association of BMI-dependent leptin GRS2* with baseline lipids among overall, drinking and non-drinking participants of the FHS third generation cohort, respectively

	Age, sex, BMI, waistadjusted model		P_interaction ^†	Fully adjusted model‡		P_interaction ^§
	Beta (SE)	P value	P_interaction ^†	Beta (SE)	P value	P_interaction ^§
HDL-C
Overall	−10.67 (6.20)	0.09	0.56	−10.98 (6.22)	0.08	0.52
Not current drinkers	−0.69 (16.31)	0.97		0.82 (16.55)	0.96
Current drinkers	−12.15 (6.64)	0.07		−11.94 (6.68)	0.07
LDL-C
Overall	−2.11 (14.05)	0.88	0.03	−2.81 (14.21)	0.84	0.02
Not current drinkers	−92.51 (43.02)	0.03		−101.15 (43.78)	0.02
Current drinkers	9.21 (14.91)	0.54		7.89 (15.02)	0.60
Log-TG
Overall	−0.59 (0.23)	0.009	0.03	−0.59 (0.23)	0.01	0.03
Not current drinkers	−2.07 (0.71)	0.004		−2.03 (0.72)	0.005
Current drinkers	−0.40 (0.24)	0.09		−0.42 (0.24)	0.08
Total cholesterol
Overall	−28.05 (15.91)	0.08	0.02	−28.74 (16.02)	0.07	0.01
Not current drinkers	−144.68 (47.61)	0.003		−151.32 (48.37)	0.002
Current drinkers	−13.19 (16.90)	0.44		−14.67 (16.98)	0.39

*GRS2 for leptin was generated by summing leptin increasing alleles of three SNPs unadjusted for BMI, weighted by their corresponding effect sizes reported by Kilpelainen et al.
†Assessed by adding an interaction term, drinking×GRS along with the drinking variable to the age, sex, BMI and waist-adjusted model among the overall participants.
‡Adjusted for age, sex, education, smoking, drinking, BMI, waist and physical activity among the overall sample.
§Assessed by adding an interaction term, drinking×GRS to the fully adjusted model among the overall participants.
BMI, body mass index; FHS, Framingham Heart Study; GRS, genetic risk score; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; log-TG, logarithmically transformed triglycerides; SE, standard error.