Table 1

Summary of biomarkers and derived variables obtained via high-throughput NMR

Metabolic groupSpecies and derived measures
Amino acidsAlanine, glutamine, glycine, histidine
Branched chain: isoleucine, leucine, valine
Aromatic: phenylalanine, tyrosine
CholesterolVLDL, LDL, HDL, HDL2, HDL3, total, free, esterified, remnant
Triglycerides and phospholipidsTriglycerides (VLDL, LDL, HDL, total)
Phosphoglycerides
Ratio of triglycerides to phosphoglycerides*
Phosphatidylcholine
Sphingomyelins
Total cholines
ApolipoproteinsApoA-1
Apo B
Ratio of ApoB/Apo A-1*
Fatty acids (FA)Total, omega-3, omega-6, PUFA, SFA
MUFA, DHA, LA
Estimated degree of unsaturation
Fatty acid ratiosOmega-3/total FA*, omega-6/total FA*, PUFA/total FA* (all %)
SFA/total FA*, MUFA/total FA*, DHA/total FA*, LA/total FA* (all %)
Lipoprotein subclasses*12 lipid measures in each of 14 subclasses
VLDL (XXL, XL, L, M, S, XS), IDL, LDL (L,M,S), HDL (XL, L, M,S): particle concentration, total lipids, esterified cholesterol, total cholesterol, phospholipids, free cholesterol, triglycerides and
esterified cholesterol/total lipids (%), free cholesterol/total lipids (%), total cholesterol/total lipids (%), triglycerides/total lipids (%) and phospholipids/total lipids (%)
Lipoprotein size*Mean diameter of VLDL, LDL and HDL particles
Ketone bodiesAcetate, acetoacetate, 3-hydroxybutyrate
Glycolysis relatedGlucose, lactate, pyruvate, citrate, glycerol
Fluid balanceCreatinine, albumin
InflammationGlycoprotein acetyls (GlycA)
  • Information obtained from https://nightingalehealth.com/science/biomarkers.

  • *Ratio.

  • ApoA-1, apolipoprotein A-1; Apo B, apolipoprotein B; DHA, docosahexaenoic acid; GlycA, glycoprotein acetyls; HDL, high-density lipoprotein; IDL, intermediate density lipoprotein; L, large; LA, linoleic acid; LDL, low-density lipoprotein; M, medium; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; S, small; SFA, saturated fatty acids; VLDL, very low-density lipoprotein; XL, very large; XXL, chylomicrons and extremely large; XS, very small.