Mediation of the associations between father’s SEP and CVD and non-CVD mortality by social and behavioural risk factors, the Stockholm Public Health Cohort (both IOW and traditional methods were used) (n=19 720)
| CVD mortality | Non-CVD mortality | |
| IRR (95% CI*) | IRR (95% CI*) | |
| Mediation by education and adult SEP | ||
| IOW approach | ||
| Total effect† | 1.24 (1.09 to 1.41) | 1.15 (1.04 to 1.27) |
| Natural direct effect‡ | 1.17 (1.00 to 1.35) | 1.09 (0.96 to 1.21) |
| Natural indirect effect | 1.06 (1.01 to 1.11) | 1.05 (1.02 to 1.09) |
| Proportion mediated§ | 29% | 38% |
| Traditional approach | ||
| Total effect† | 1.24 (1.09 to 1.41) | 1.15 (1.04 to 1.27) |
| Direct effect¶ | 1.14 (0.99 to 1.32) | 1.09 (0.96 to 1.21) |
| Indirect effect | 1. 08 (1.05 to 1.12) | 1.05 (1.03 to 1.08) |
| Proportion mediated§ | 39% | 38% |
| Mediation by education, adult SEP+behavioural factors | ||
| IOW approach | ||
| Total effect† | 1.24 (1.09 to 1.41) | 1.15 (1.04 to 1.27) |
| Natural direct effect‡ | 1.13 (0.99 to 1.30) | 1.09 (0.97 to 1.21) |
| Natural indirect effect | 1.09 (1.04 to 1.14) | 1.06 (1.01 to 1.10) |
| Proportion mediated§ | 44% | 42% |
| Traditional approach | ||
| Total effect† | 1.24 (1.09 to 1.41) | 1.15 (1.04 to 1.27) |
| Direct effect¶ | 1.10 (0.96 to 1.26) | 1.08 (0.97 to 1.20) |
| Indirect effect | 1. 13 (1.08 to 1.18) | 1.07 (1.03 to 1.10) |
| Proportion mediated§ | 59% | 49% |
*Percentile-based bootstrap CIs are reported.
↵†Adjusted for age, gender, country of birth and marital status.
↵‡Obtained by applying the inverse odds weights in addition to adjusting for age, gender, country of birth and marital status.
↵§The proportion mediated was calculated using the formula: {IRRNDE (IRRNIE− 1)/(IRRNDE * IRRNIE− 1)}*100.
↵¶Adjusted for age, gender, country of birth, marital status and the mediators of interest.
CVD, cardiovascular diseases; IOW, inverse odds weighting; IRR, incidence rate ratio; SEP, socioeconomic position.