Prevalence of potential therapeutic indications: depression, other mental health problems and chronic pain among new antidepressant users, and the proportion of persons with depression who had other concurrent mental health problems or pain by jurisdiction
| Canada | USA | UK | Taiwan | |||
| Ontario sample (n=60 366 patients) | Montreal sample (n=13 303 patients) | Quebec City and Montreal (n=1308 patients) | Boston (n=10 131 patients) | CPRD (n=15 868 patients) | NHIRDB (n=17 580 patients) | |
| Depression | ||||||
| Prevalence, N (%) | 7484 (12.4) | 2333 (17.5) | 563 (43.0) | 2203 (21.7) | 2478 (15.6) | 1603 (9.1) |
| Alcohol/Drug abuse | ||||||
| Prevalence, N (%) | 1989 (3.3) | 326 (2.5) | 23 (1.8) | 290 (2.9) | 4188 (26.4) | 224 (1.3) |
| Abuse in depressed, N (%) | 450 (6.0) | 97 (4.2) | 12 (2.1) | 194 (8.8) | 795 (32.1) | 25 (1.6) |
| Prevalence ratio | 2.1 | 2.0 | 1.4 | 7.3 | 1.3 | 1.3 |
| Anxiety | ||||||
| Prevalence, N (%) | 23 374 (38.7) | 3641 (27.4) | 465 (35.6) | 1798 (17.7) | 1914 (12.1) | 6277 (35.7) |
| Anxiety in depressed, N (%) | 3684 (49.2) | 807 (34.6) | 218 (38.7) | 905 (41.1) | 588 (23.7) | 767 (47.8) |
| Prevalence ratio | 1.3 | 1.3 | 1.2 | 3.6 | 2.4 | 1.4 |
| Major mental illness | ||||||
| Prevalence, N (%) | 2627 (4.4) | 692 (5.2) | 50 (3.8) | 502 (5.0) | 253 (1.6) | 570 (3.2) |
| Mental illness in depressed, N (%) | 1473 (19.7) | 225 (9.6) | 23 (4.1) | 323 (14.7) | 79 (3.2) | 95 (5.9) |
| Prevalence ratio | 9.0 | 2.3 | 1.1 | 6.5 | 2.5 | 2.0 |
| Suicide attempt | ||||||
| Prevalence, N (%) | 101 (0.2) | 30 (0.2) | – | 72 (0.7) | 129 (0.8) | 6 (0.0) |
| Suicide attempt in depressed, N (%) | 80 (1.1) | 8 (0.3) | – | 67 (3.0) | 67 (2.7) | 2 (0.1) |
| Prevalence ratio | 26.9 | 1.7 | – | 48.2 | 5.8 | 5.0 |
| Chronic pain | ||||||
| Prevalence, N (%) | 28 687 (47.5) | 6379 (48.0) | 571 (43.7) | 5200 (51.3) | 6539 (41.2) | 11 994 (68.2) |
| Pain in depressed, N (%) | 3591 (48.0) | 1105 (47.4) | 235 (41.7) | 1365 (62.0) | 1021 (41.2) | 994 (62.0) |
| Prevalence ratio | 1.0 | 1.0 | 0.9 | 1.3 | 1.0 | 0.9 |
CPRD, Clinical Practice Research Datalink; NHIRDB, National Health Insurance Research Database.