Table 1

Schedule of events

Visit no	Study visits
	Week, day
	W-4 to −1 Screening	W0, D1 Baseline	W1, D1 (±1 day)	W4, D1 (±3 days)	W12, D1 (±3 days)	W24, D1 (±3 days)
	V1	V2	V3	V4	V5	V6/final
Consent form	X	X
Medical history	X
Concomitant medication	X	X	X	X	X
Eligibility criteria	X	X
Physical examination	X	X		X	X
Adverse events		X	X	X	X	X
Haematology*	X	X		X	X
Chemistry†	X	X		X	X
T-cell activation and inflammatory markers		X			X	X
HIV viral load	X	X		X	X	X
Size of HIV reservoir in latently infected CD4+ T cells		X			X	X
Urine pregnancy test	X	X
Metformin administration			X	X	X
Colon mucosal biopsies‡		X			X
Stool sample collection for microbiota analysis		X			X	X

↵*Complete blood count, CD4+ and CD8+ T cell counts.
↵†AST, ALT, Alk Phos, total bilirubin, triglycerides, cholesterol, HDL, LDL, creatinine, blood glucose, lipase, amylase, urea, creatine kinase, serum phosphate and fasting glucose.
‡Optional procedure.
AST, aspartate aminotransferase; ALT, alanine aminotransferase; Alk Phos, alkaline phosphatase; HDL, high-density lipoprotein; LDL, low-density lipoprotein.