Cox model with HRs and 95% CIs for fibromyalgia associated with migraine and covariates
| Variable | Crude | Adjusted† | ||
| HR | (95% CI) | HR | (95% CI) | |
| Migraine | 1.57 | (1.44 to 1.70)*** | 1.51 | (1.38 to 1.65)*** |
| Sex (Women vs Men) | 1.05 | (0.97 to 1.15) | – | – |
| Age, years | 1.02 | (1.02 to 1.03)*** | 1.02 | (1.01 to 1.02)*** |
| Baseline comorbidities (yes vs no) | ||||
| Diabetes | 1.58 | (1.36 to 1.82)*** | 0.99 | (0.85 to 1.16) |
| Hypertension | 1.81 | (1.67 to 1.96)*** | 1.10 | (0.99 to 1.22) |
| Hyperlipidaemia | 1.69 | (1.54 to 1.85)*** | 1.15 | (1.03 to 1.28)* |
| Depression | 1.38 | (1.17 to 1.63)*** | 1.06 | (0.89 to 1.26) |
| Anxiety | 1.34 | (1.19 to 1.51)*** | 0.92 | (0.80 to 1.05) |
| Sleep disorder | 1.45 | (1.33 to 1.58)*** | 1.09 | (0.98 to 1.20) |
| CAD | 1.74 | (1.57 to 1.94)*** | 1.01 | (0.89 to 1.14) |
| CFS | 2.11 | (0.79 to 5.62) | – | – |
| IBS | 1.28 | (1.06 to 1.53)** | 0.94 | (0.78 to 1.13) |
*P<0.05; **P<0.01; ***P<0.001.
†Multivariable analysis including age and the comorbidities of diabetes, hypertension, hyperlipidaemia, anxiety, sleep disorders, stroke, and peptic ulcer disease and use of non-steroidal anti-inflammatory drugs.
CAD, coronary artery disease; CFS, chronic fatigue syndrome; IBS, irritable bowel syndrome.