Demographics and baseline characteristics of enrolled patients
| Variable | Bimatoprost–timolol | Total (n=121) | |
| BAK preserved (n=76) | PF (n=45) | ||
| Mean age, years | 66.14 | 67.02 | 66.47 |
| SD | 10.17 | 10.71 | 10.34 |
| Sex, n (%) | |||
| Male | 34 (44.7) | 21 (46.7) | 55 (45.5) |
| Female | 42 (55.3) | 24 (53.3) | 66 (54.5) |
| Race, n (%) | |||
| Caucasian | 76 (100) | 45 (100) | 121 (100) |
| Hyperaemia, n (%) | 76 (100) | 45 (100) | 121 (100) |
| Hyperaemia grade, mean Ora calibraTM redness scale (SD) | 2.24 (0.43) | 2.30 (0.48) | 2.26 (0.45) |
| Severity of worst ocular symptom, n (%) | |||
| Mild | 30 (39.5) | 17 (37.8) | 47 (38.8) |
| Moderate | 39 (51.3) | 23 (51.1) | 62 (51.2) |
| Severe | 7 (9.2) | 5 (11.1) | 12 (9.9) |
| Abnormal ocular signs, n (%) | |||
| Fluorescein tear break-up time | 52 (68.4) | 32 (71.1) | 84 (69.4) |
| Corneal fluorescein staining | 63 (82.9) | 42 (93.3) | 105 (86.8) |
| Conjunctival fluorescein staining | 55 (72.4) | 36 (80.0) | 91 (75.2) |
| Blepharitis | 32 (42.1) | 22 (48.9) | 54 (44.6) |
| Tear secretion/Schirmer test | 47 (61.8) | 29 (64.4) | 76 (62.8) |
| Abnormal ocular symptoms, n (%) | |||
| Irritation/burning/stinging | 55 (72.4) | 32 (71.1) | 87 (71.9) |
| Foreign body sensation | 41 (53.9) | 19 (42.2) | 60 (49.6) |
| Tearing | 31 (40.8) | 25 (55.6) | 56 (46.3) |
| Itching | 36 (47.4) | 26 (57.8) | 62 (51.2) |
| Dry eye sensation | 49 (64.5) | 28 (62.2) | 77 (63.6) |
Please refer to online supplementary table S2 for criteria of abnormal signs and symptoms.
BAK, benzalkonium chloride; PF, preservative-free.