Characteristics of weekday and weekend liver-only transplants in the UK, 1 January 2000 to 31 December 2014
Weekday transplant | Weekend transplant | P value | |
N (%) unless otherwise stated | |||
Total number of transplants | 5613 (64) | 3203 (36) | |
Recipient characteristics | |||
Transplant year | |||
2000 | 312 (6) | 209 (7) | |
2001 | 345 (6) | 188 (6) | |
2002 | 335 (6) | 232 (7) | |
2003 | 288 (5) | 207 (6) | |
2004 | 340 (6) | 239 (7) | |
2005 | 315 (6) | 172 (5) | |
2006 | 321 (6) | 196 (6) | 0.002 |
2007 | 341 (6) | 198 (6) | |
2008 | 379 (7) | 195 (6) | |
2009 | 379 (7) | 187 (6) | |
2010 | 379 (7) | 212 (7) | |
2011 | 406 (7) | 209 (7) | |
2012 | 441 (8) | 227 (7) | |
2013 | 511 (9) | 246 (8) | |
2014 | 521 (9) | 286 (9) | |
Super-urgent | 803 (14) | 523 (16) | 0.01 |
Age at transplant, mean (SD) | 50 (13) | 50.2 (12) | 0.5 |
Male gender | 3405 (61) | 1899 (59) | 0.2 |
Caucasian | 4922 (88) | 2814 (88) | 0.8 |
MELD at transplant, mean (SD) | 19.1 (9) | 19.5 (9) | 0.05 |
UKELD at transplant, mean (SD) | 56.0 (6) | 56.4 (7) | 0.02 |
Primary liver disease | |||
Cancer | 320 (6) | 171 (5) | |
Hepatitis C infection | 746 (13) | 395 (12) | |
Alcohol related liver disease | 1180 (21) | 626 (20) | |
Hepatitis B infection | 153 (3) | 107 (3) | |
Primary Sclerosing Cholangitis | 451 (8) | 276 (9) | 0.14 |
Primary Biliary Cholangitis | 520 (9) | 333 (10) | |
Autoimmune hepatitis | 453 (8) | 255 (8) | |
Metabolic liver disease | 316 (6) | 172 (5) | |
Acute liver disease | 647 (12) | 414 (13) | |
Retransplant | 539 (10) | 304 (9) | |
Other | 288 (5) | 150 (5) | |
ABO blood group | |||
O | 2405 (43) | 1318 (41) | |
A | 2338 (42) | 1341 (42) | 0.01 |
B | 648 (12) | 372 (12) | |
AB | 222 (4) | 172 (5) | |
Renal support | 690 (12) | 421 (13) | 0.2 |
Inpatient | 1585 (28) | 975 (30) | 0.03 |
Ventilated | 585 (10) | 373 (12) | 0.08 |
Oesophageal varices | 3406 (61) | 1991 (62) | 0.17 |
Presence of TIPS | 185 (3) | 130 (4) | 0.06 |
Sepsis confirmed | 224 (4) | 175 (5) | 0.001 |
Portal vein thrombosis | 104 (2) | 61 (2) | 0.9 |
BMI kg/m2, mean (SD) | 26.4 (5) | 26.4 (5) | 0.5 |
Donor characteristics | |||
Donor age, mean (SD) | 46.4 (15) | 46 (16) | 0.3 |
DCD | 596 (11) | 333 (10) | 0.7 |
Split liver | 398 (7) | 190 (6) | 0.04 |
Organ appearance suboptimal | 1208 (22) | 653 (20) | 0.2 |
Cause of death | |||
CVA | 3736 (67) | 2174 (68) | |
Miscellaneous | 1186 (21) | 572 (18) | 0.0002 |
RTA | 410 (7) | 293 (9) | |
Other trauma | 281 (5) | 164 (5) | |
Operative characteristics | |||
Night-time procurement | 3799 (68) | 2429 (76) | <0.0001 |
Night-time transplant | 3715 (66) | 2386 (74) | <0.0001 |
CIT (hours), mean (SD) | 9.3 (3) | 9.4 (3) | 0.24 |
Previous abdominal surgery | 1115 (20) | 670 (21) | 0.2 |
Failure | |||
Overall graft failure (%) | |||
30 days | 6 | 5 | 0.08 |
1 year | 11 | 10 | 0.16 |
3 years | 15 | 14 | 0.16 |
Overall transplant failure (%) | |||
30 days | 8 | 7 | 0.01 |
1 year | 16 | 14 | 0.09 |
3 years | 22 | 20 | 0.12 |
Cause of death at 30 days | 229 (4) | 120 (4) | |
Cardiothoracic/myocardial ischaemia and infarction | 29 (13) | 17 (14) | |
CVA | 11 (5) | 2 (2) | |
Haemorrhage | 15 (7) | 7 (6) | 0.3 |
Infection/septicaemia | 32 (14) | 15 (13) | |
Multisystem failure | 67 (29) | 47 (39) | |
Other | 75 (33) | 32 (27) | |
Cause of graft failure at 30 days | 314 (6) | 152 (5) | |
Biliary complications | 6 (2) | 4 (3) | |
Hepatic artery thrombosis | 95 (30) | 42 (28) | |
Non-thrombotic infarction | 14 (4) | 12 (8) | 0.6 |
Primary non-function | 93 (30) | 50 (33) | |
Rejection | 7 (2) | 3 (2) | |
Other | 99 (32) | 41 (27) |
BMI, body mass index; CIT, cold ischaemia time; CVA, cerebrovascular accident; DCD, donation after cardiac death; MELD, model of end-stage liver disease; RTA, road traffic accident; UKELD, UK model for end-stage liver disease.