Suggested titration schedule for group 2: high CBD dose TN-TC19LM oral capsules
| Weeks | Daily dose | Number of capsules |
| 1 | 5 mg THC/ 45 mg CBD | One capsule daily, taken orally. |
| 2 | 10 mg THC/ 90 mg CBD | One capsule twice daily, taken orally (two capsules per day). |
| 3 | 15 mg THC/ 135 mg CBD | One capsule three times daily, taken orally (three capsules daily). |
| 4 | 20 mg THC/ 180 mg CBD | One capsule four times daily, taken orally (four capsules). |
| 5–12 | 25 mg THC/ 225 mg CBD | One capsule five times daily, taken orally (five capsules). |
Group 2: high CBD dose TN-TC19LM (5 mg THC/45 mg CBD capsules). This group will be advised to start by taking one capsule once daily for 1 week (5 mg THC/45 mg CBD) and increase the number of capsules as tolerated to a maximum of 10 capsules daily by week 5 (25 mg THC/225 mg CBD total). Participants will record the times and dates of all capsules consumed in a log book.
CBD, cannabidiol; THC, tetrahydrocannabinol.