Estimated ratios of CA versus 28-day episode-level counts (diagnosis hierarchy approach) from 2000 to 2013, by CHD subtype, sex and age group
| Diagnosis | Sex | Age group | Ratio (CI) in 2000 | Ratio (CI) in 2013 | Trend coefficient (P value) | P values for tests comparing | |||
| Year | Year squared | Sex* | Age group* | Sex × age group | |||||
| STEMI† | F | 35–54 | 1.10 (1.05 to 1.14) | 1.01 (0.99 to 1.03) | −0.0064 (0.000) | ||||
| F | 55–74 | 1.08 (1.06 to 1.09) | 1.01 (1.00 to 1.02) | −0.0064 (0.000) | |||||
| F | 75–84 | 1.05 (1.03 to 1.06) | 1.03 (1.02 to 1.05) | −0.0064 (0.000) | 0.946 | 0.000 | 0.799 | ||
| M | 35–54 | 1.09 (1.06 to 1.11) | 1.01 (0.98 to 1.03) | −0.0064 (0.000) | |||||
| M | 55–74 | 1.08 (1.07 to 1.09) | 1.01 (1.00 to 1.02) | −0.0064 (0.000) | |||||
| M | 75–84 | 1.05 (1.04 to 1.06) | 1.04 (1.02 to 1.06) | −0.0064 (0.000) | |||||
| NSTEMI‡ | F | 35–54 | 1.10 (1.06 to 1.14) | 1.05 (1.03 to 1.08) | −0.0036 (0.000) | ||||
| F | 55–74 | 1.07 (1.06 to 1.09) | 1.03 (1.01 to 1.04) | −0.0036 (0.000) | |||||
| F | 75–84 | 1.08 (1.06 to 1.10) | 1.04 (1.02 to 1.05) | −0.0036 (0.000) | 0.470 | 0.937 | 0.033 | ||
| M | 35–54 | 1.08 (1.06 to 1.10) | 1.03 (1.02 to 1.05) | −0.0036 (0.000) | |||||
| M | 55–74 | 1.10 (1.08 to 1.12) | 1.05 (1.04 to 1.07) | −0.0036 (0.000) | |||||
| M | 75–84 | 1.09 (1.07 to 1.11) | 1.04 (1.03 to 1.06) | −0.0036 (0.000) | |||||
| Unstable angina§ | F | 35–54 | 1.15 (1.13 to 1.17) | 1.09 (1.07 to 1.10) | −0.0124 (0.000) | 0.0006 (0.001) | |||
| F | 55–74 | 1.15 (1.14 to 1.17) | 1.09 (1.08 to 1.10) | −0.0124 (0.000) | 0.0006 (0.001) | ||||
| F | 75–84 | 1.17 (1.15 to 1.19) | 1.11 (1.09 to 1.12) | −0.0124 (0.000) | 0.0006 (0.001) | 0.000 | 0.040 | 0.017 | |
| M | 35–54 | 1.18 (1.16 to 1.20) | 1.12 (1.10 to 1.14) | −0.0124 (0.000) | 0.0006 (0.001) | ||||
| M | 55–74 | 1.21 (1.19 to 1.22) | 1.15 (1.13 to 1.16) | −0.0124 (0.000) | 0.0006 (0.001) | ||||
| M | 75–84 | 1.20 (1.18 to 1.21) | 1.13 (1.12 to 1.15) | −0.0124 (0.000) | 0.0006 (0.001) | ||||
| Stable angina§ | F | 35–54 | 1.14 (1.12 to 1.16) | 1.08 (1.07 to 1.10) | −0.0115 (0.000) | 0.0006 (0.004) | |||
| F | 55–74 | 1.15 (1.14 to 1.17) | 1.10 (1.09 to 1.11) | −0.0115 (0.000) | 0.0006 (0.004) | ||||
| F | 75–84 | 1.14 (1.12 to 1.16) | 1.08 (1.07 to 1.10) | −0.0115 (0.000) | 0.0006 (0.004) | 0.000 | 0.009 | 0.097 | |
| M | 35–54 | 1.20 (1.18 to 1.23) | 1.15 (1.13 to 1.16) | −0.0115 (0.000) | 0.0006 (0.004) | ||||
| M | 55–74 | 1.20 (1.18 to 1.22) | 1.14 (1.13 to 1.15) | −0.0115 (0.000) | 0.0006 (0.004) | ||||
| M | 75–84 | 1.18 (1.16 to 1.20) | 1.13 (1.11 to 1.14) | −0.0115 (0.000) | 0.0006 (0.004) | ||||
| Other CHD§ | F | 35–54 | 1.18 (1.15 to 1.22) | 1.11 (1.08 to 1.14) | −0.0211 (0.000) | 0.0012 (0.000) | |||
| F | 55–74 | 1.19 (1.16 to 1.22) | 1.12 (1.10 to 1.14) | −0.0211 (0.000) | 0.0012 (0.000) | ||||
| F | 75–84 | 1.19 (1.16 to 1.21) | 1.11 (1.09 to 1.13) | −0.0211 (0.000) | 0.0012 (0.000) | 0.000 | 0.359 | 0.542 | |
| M | 35–54 | 1.22 (1.20 to 1.25) | 1.15 (1.13 to 1.17) | −0.0211 (0.000) | 0.0012 (0.000) | ||||
| M | 55–74 | 1.23 (1.20 to 1.25) | 1.15 (1.14 to 1.17) | −0.0211 (0.000) | 0.0012 (0.000) | ||||
| M | 75–84 | 1.21 (1.19 to 1.24) | 1.14 (1.12 to 1.15) | −0.0211 (0.000) | 0.0012 (0.000) | ||||
*P values for sex and age group are from the respective models but without the age group × sex interaction term.
†From the model: ratio=constant + (admission year – 2000) + age group + sex + age group × sex + age × (admission year – 2000).
‡From the model: ratio=constant + (admission year – 2000) + age group + sex + age group × sex.
§From the model: ratio=constant + (admission year – 2000) + age group + sex + age group × sex + (admission year – 2000)2.
CA, contiguous admission; CHD, coronary heart disease; F, female; M, male; NSTEMI, non-STEMI; STEMI, ST elevation myocardial infarction.