Total testosterone: comparison of model with age and ethnicity only, model including age, ethnicity, smoking, cholesterol, haemoglobin, blood pressure and drinking, model including all these and the Charlson Index. Associations with baseline models and with longitudinal change.
| Basic baseline model* | Complex baseline model† | Complex baseline model with comorbidities‡ | Change Wave 1 to Wave 2§ | Change Wave 1 to Wave 3§ | ||||||
| β and 95% CI | p Value | β and 95% CI | p Value | β and 95% CI | p Value | β and 95% CI | p Value | β and 95% CI | p Value | |
| NEADL | −1.292 (−2.314 to 0.27) | 0.014 | −1.237 (−2.262 to 0.213) | 0.019 | −1.265 (−2.295 to 0.235) | 0.017 | 0.28 (−0.58 to 1.141) | 0.52 | 0.082 (−1.059 to 1.223) | 0.89 |
| SF-12 PHC | −1.828 (−5.43 to 1.774) | 0.32 | −1.562 (−5.246 to 2.122) | 0.407 | −1.723 (−5.424 to 1.977) | 0.36 | −0.891 (−4.168 to 2.387) | 0.6 | −1.681 (−5.602 to 2.24) | 0.4 |
| SF-12 MHC | −0.432 (−2.651 to 1.788) | 0.7 | 0.341 (−1.895 to 2.577) | 0.766 | 0.381 (−1.87 to 2.631) | 0.74 | 1.238 (−1.735 to 4.21) | 0.42 | −2.497 (−6.057 to 1.064) | 0.17 |
| Fried score | 0.512 (0.19 to 0.834) | 0.0021 | 0.392 (0.060 to 0.724) | 0.022 | 0.41 (0.077 to 0.743) | 0.017 | 0.054 (−0.304 to 0.411) | 0.77 | 0.214 (−0.185 to 0.614) | 0.3 |
Associations with baseline models and with longitudinal change.
Comparing the lowest quartile of total testosterone with all others.
*Cross-sectional model adjusted for age and ethnicity.
†Cross-sectional model adjusted for age, ethnicity, smoking status, cholesterol, haemoglobin, fasting glucose, systolic blood pressure, alcohol intake and Fried score.
‡Cross-sectional model adjusted for age, ethnicity, smoking status, cholesterol, haemoglobin, fasting glucose, systolic blood pressure, alcohol intake, Charlson Index score and Fried score.
§Predictive model adjusted for age, ethnicity, smoking status, cholesterol, haemoglobin, fasting glucose, systolic blood pressure, alcohol intake, Charlson Index score and Fried score.
NEADL, Nottingham Extended Activities of Daily Living; SF-12 PHC, Physical Health Component summary score of the SF-12; SF-12 MHC, Mental Health Component summary score of the SF-12.