Sensitivity and specificity of all clinical and dermoscopy CPRs
| Rule name | Cut-point | Sensitivity* | Specificity* |
|---|---|---|---|
| Clinical rules | |||
| ABCDE | ≥1 | Two studies 0.47–0.92 (mean 0.70) | One study 0.56 |
| ≥2 | 0.85 | 0.44 | |
| 7-point checklist | ≥3 | Three studies 0.44–0.86 (mean 0.70) | Three studies 0.62–0.94 (mean 0.74) |
| Revised 7-point checklist | ≥3 | 0.92 | 0.33 |
| ABCD rule | ≥1 | 0.84 | 0.78 |
| Dermoscopic rules | |||
| ABCD rule | ≥4.75 | Meta-analysis (eight studies) 0.85 (95% CI 0.73 to 0.93) | Meta-analysis (eight studies) 0.72 (95% CI 0.65 to 0.78) |
| ≥5.45 | Four studies 0.73–0.98 (mean 0.85) | Four studies 0.46–0.91 (mean 0.79) | |
| ≥4.2 | 0.88 | 0.64 | |
| 7-point checklist | ≥3 | Meta-analysis (11 studies) 0.77 (95% CI 0.61 to 0.88) | Meta-analysis (11 studies) 0.80 (95% CI 0.59 to 0.92) |
| Menzies 1996 for melanoma | ≥1 | Six studies 0.85–0.95 (mean 0.91) | Six studies 0.38–0.78 (mean 0.69) |
| 3-point checklist | ≥1 | Five studies 0.50–0.96 (mean 0.84) | Four studies 0.31–0.72 (mean 0.55) |
| Seven features for melanoma (7FFM) | ≥2 | Five studies 0.69–0.95 (mean 0.86) | Five studies 0.74–0.86 (mean 0.82) |
| CASH algorithm | ≥8 | Three studies 0.41–0.92 (mean 0.73) | Three studies 0.65–0.97 (mean 0.82) |
| The 3-colour test | ≥3 | Two studies 0.77–0.97 (mean 0.87) | Two studies 0.55–0.90 (mean 0.73) |
| Revised 7-point checklist | ≥1 | 0.88 | 0.28 |
| Kreusch 1992 | Not reported | 0.99 | 0.94 |
| Nilles 1994 | Not reported | 0.90 | 0.85 |
| Menzies 2008 for melanoma | ≥1 | 0.70 | 0.56 |
| DynaMel algorithm | ≥3 | 0.77 | 0.98 |
| Menzies 2008 for skin cancer | ≥0 (high sensitivity); ≥1 (high specificity) | 0.95 | 0.80 |
| Simplified ABC-point list | ≥4 | 0.90 | 0.87 |
| AC rule | Not reported | 0.91 | 0.94 |
| Emery 2010 SIAscopy | ≥6 | 0.50 | 0.84 |
| Guitera RCM 2012 | Not reported | 0.88 | 0.71 |
| ABCDE rule | Not reported | Not reported | Not reported |
*Where sensitivity and specificity are presented for more than one study, the range and mean are presented. Where meta-analysis was possible, values from meta-analysis are presented with 95% CIs.
ABC, Asymmetry, irregular Borders, more than one or uneven distribution of Colour; ABCD, Asymmetry, irregular Borders, more than one or uneven distribution of Colour, or a large (greater than 6 mm) Diameter; ABCDE, Asymmetry, irregular Borders, more than one or uneven distribution of Color, or a large (greater than 6mm) Diameter, Evolution of moles; AC, asymmetry, colour variation; CASH, color, architecture, symmetry, and homogeneity; CPR, clinical prediction rules; RCM, reflectance confocal microscopy.