Table 5

Patient-reported health utility, health-related quality of life and psychological well-being outcomes late stage prostate cancer—RoI versus NI

	Weighted mean		Univariate model			Multivariate model 1*			Multivariate model 2†
			NI vs RoI (ie, RoI is baseline)			NI vs RoI (ie, RoI is baseline)			NI vs RoI (ie, RoI is baseline)
Outcome scale	RoI	NI	Coefficient	95% CI	p Value	Coefficient	95% CI	p Value	Coefficient	95% CI	p Value
Health utilities
EQ-5D-5L score	0.8	0.7	−0.061	0.102 to 0.020	0.004	−0.030	0.071 to 0.011	0.151	−0.027	0.071 to 0.017	0.233
Health-related quality of life
C30: global health status	67.8	71.2	3.405	−0.374 to 7.183	0.077	5.996	2.310 to 9.681	0.001‡	5.472	1.525 to 9.420	0.007
QLC-C30: physical functioning	78.6	75.2	−3.432	−7.457 to 0.594	0.095	0.476	−3.450 to 4.402	0.812	1.174	−3.174 to 5.522	0.596
QLC-C30: role functioning	75.7	72.2	−3.520	−8.653 to 1.613	0.179	0.140	−5.055 to 5.335	0.958	1.355	−4.423 to 7.134	0.645
QLC-C30: emotional functioning	81.0	82.1	1.091	−2.532 to 4.715	0.554	3.014	−0.614 to 6.643	0.103	3.750	−0.280 to 7.781	0.068
QLC-C30: cognitive functioning	79.9	79.3	−0.538	−4.367 to 3.291	0.783	1.754	−1.990 to 5.498	0.358	1.818	−2.300 to 5.937	0.386
QLC-C30: social functioning	76.4	76.6	0.231	−4.245 to 4.707	0.919	2.581	−1.991 to 7.154	0.268	2.915	−2.081 to 7.911	0.252
QLC-C30: fatigue	27.1	31.6	4.542	0.322 to 8.762	0.035	0.838	−3.352 to 5.028	0.695	−0.607	−5.189 to 3.976	0.795
QLC-C30: nausea and vomiting	6.2	5.3	−0.844	−3.227 to 1.540	0.487	−1.762	−4.426 to 0.903	0.195	−1.949	−4.800 to 0.902	0.180
QLC-C30: pain	17.5	23.8	6.325	1.986 to 10.664	0.004	3.689	−0.715 to 8.094	0.101	2.638	−2.218 to 7.494	0.287
QLC-C30: dyspnoea	20.3	22.9	2.611	−2.213 to 7.434	0.288	−1.720	−6.391 to 2.951	0.470	−3.083	−8.216 to 2.050	0.239
QLC-C30: insomnia	26.2	26.7	0.518	−4.594 to 5.629	0.842	−2.442	−7.522 to 2.638	0.346	−3.823	−9.618 to 1.972	0.196
QLC-C30: appetite loss	8.4	9.8	1.335	−1.990 to 4.661	0.431	−0.716	−4.357 to 2.926	0.700	−1.686	−5.641 to 2.268	0.403
QLC-C30: constipation	14.4	14.3	−0.069	−4.036 to 3.898	0.973	−2.397	−6.641 to 1.847	0.268	−2.738	−7.258 to 1.783	0.235
QLC-C30: diarrhoea	11.4	12.2	0.793	−2.844 to 4.430	0.669	−0.566	−4.298 to 3.165	0.766	−1.182	−5.181 to 2.817	0.562
QLC-C30: financial difficulties	17.9	10.4	−7.454	−11.176 to −3.731	0.0001‡	−8.137	−11.772 to −4.503	0.0001‡	−8.629	−12.770 to −4.488	0.0001‡
Psychological well-being
DASS: stress	5.7	6.3	0.644	−0.805 to 2.093	0.383	0.360	−1.062 to 1.781	0.620	0.743	−0.816 to 2.301	0.350
DASS: anxiety	3.9	4.4	0.477	−0.641 to 1.596	0.402	−0.151	−1.292 to 0.991	0.796	−0.086	−1.342 to 1.170	0.893
DASS: depression	5.1	5.7	0.581	−0.871 to 2.033	0.432	0.080	−1.366 to 1.526	0.914	0.172	−1.431 to 1.775	0.833

Results are weighted by country, age at diagnosis and time since diagnosis.
Higher symptom scores indicate more/worse symptoms or, where appropriate, better functioning or quality of life.
*Logistic regression model adjusted for current age, number of comorbidities, time since diagnosis and method of diagnosis.
†Logistic regression model adjusted for age, number of comorbidities, time since diagnosis, method of diagnosis, treatment type—prostatectomy, external beam radiotherapy, brachytherapy and androgen deprivation therapy.
‡Significant difference between countries.
NI, Northern Ireland; RoI, Republic of Ireland.