Prostate cancer-related physical symptoms—late disease patients
| Stage III/IV—any Gleason | Univariate model | Multivariate model 1* | Multivariate model 2† | ||
|---|---|---|---|---|---|
| Weighted proportion | OR | OR | OR | ||
| (NI vs RoI) | (NI vs RoI) | (NI vs RoI) | |||
| Ongoing side effect | RoI (%) | NI (%) | (RoI as baseline) | (RoI as baseline) | (RoI as baseline) |
| Urinary incontinence | 22.2 | 15.9 | 0.65 | 0.66 | 0.88 |
| (0.44 to 0.97) p=0.035 | (0.44 to 0.99) p=0.047 | (0.55 to 1.41) p=0.591 | |||
| Loss of libido | 51.6‡ | 64.7‡ | 1.68‡ | 1.61‡ | 1.32 |
| (1.22 to 2.31) p=0.001 | (1.16 to 2.23) p=0.005 | (0.92 to 1.90) p=0.129 | |||
| Erectile dysfunction | 66.9 | 66.4 | 0.95 | 1.09 | 1.29 |
| (0.68 to 1.33) p=0.784 | (0.77 to 1.55) p=0.623 | (0.87 to 1.89) p=0.202 | |||
| Bowel problems | 14.2 | 21.7 | 1.60 | 1.40 | 1.19 |
| (1.07 to 2.39) p=0.021 | (0.90 to 2.16) p=0.133 | (0.75 to 1.87) p=0.458 | |||
| Breast changes (gynaecomastia) | 9.4‡ | 23.3‡ | 2.80‡ | 3.09‡ | 2.30‡ |
| (1.81 to 4.32) p<0.001 | (1.94 to 4.91) p<0.001 | (1.41 to 3.73) p=0.001 | |||
| Hot flashes | 18.8‡ | 41.1‡ | 2.95‡ | 2.79‡ | 2.33‡ |
| (2.08 to 4.18) p<0.001 | (1.95 to 3.99) p<0.001 | (1.55 to 3.51) p<0.001 | |||
| Fatigue | 24.6‡ | 39.0‡ | 1.93‡ | 1.71‡ | 1.53 |
| (1.39 to 2.70) p<0.001 | (1.20 to 2.44) p=0.003 | (1.05 to 2.23) p=0.028 | |||
Results are weighted by country, age at diagnosis and time since diagnosis.
*Logistic regression model adjusted for current age, number of comorbidities, time since diagnosis and method of diagnosis.
†Logistic regression model adjusted for above plus prostatectomy, external beam radiotherapy, brachytherapy and hormone therapy records with missing treatment or method of diagnosis dropped from all models (n=12). Significant difference at p<0.05 but with Bonferroni correction applied.
‡Significant difference between countries with RoI as baseline.
NI, Northern Ireland; RoI, Republic of Ireland.