RT Journal Article
SR Electronic
T1 User perspectives, challenges and opportunities in the implementation of protein-to-creatinine dipstick test for proteinuria detection in Ghana: a mixed methods study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e084978
DO 10.1136/bmjopen-2024-084978
VO 15
IS 5
A1 Amoakoh, Hannah Brown
A1 Browne, Joyce L
A1 Zobrist, Stephanie
A1 Arhinful, Daniel
A1 Owusu, Rosemond
A1 Ampofo, Nana Kwame Asare
A1 Yeboah, Abena Odurowaa
A1 Cofie, Patience
A1 Srofenyoh, Emmanuel
A1 Adu-Bonsaffoh, Kwame
A1 Yevoo, Linda Lucy
A1 Wuobar, Francis Vinkpenubar
A1 Metzler, Mutsumi
A1 Coffey, Patricia S
YR 2025
UL http://bmjopen.bmj.com/content/15/5/e084978.abstract
AB Objective To assess the appropriateness, acceptability and feasibility of implementing the Test-it PrCr Urinalysis Dipstick Test (LifeAssay Diagnostics, South Africa) in referral hospitals in Ghana.Participants 96 healthcare professionals were trained on the protein-to-creatinine (PrCr) test, which was integrated into protocols alongside standard-of-care tests between November 2021 and April 2022. Test users completed questionnaires post training. Three focus group discussions (FGDs) and seven key informant interviews were conducted to evaluate test procedure comprehension, insights into training effectiveness, usability/user confidence, perceptions, attitudes towards the test and barriers and facilitators of use.Results High product usability, user confidence and satisfaction were reported. Staff perceived the test as easy to use and similar to current products. Misinterpretations of test results were less likely for strong results. Facilitators of use included effective trainings, sensitisation of the product and key stakeholder endorsement. Challenges impacting implementation feasibility included the short shelf life of test strips (3 months) after opening cannisters, the added complexity of the ratiometric result interpretation and the test’s lack of other parameters that are included in current products (eg, glucose, nitrate), limiting its broader clinical utility for antenatal care screening. All FGD participants agreed that the use of the PrCr test would not change current practices/protocols for dipstick use.Conclusion Although the Test-It PrCr test is easy to use and well accepted, key product attributes limit its implementation feasibility in this setting. It may be more appropriate for monitoring high-risk women in this context.Data are available upon reasonable request. All data are available upon reasonable request by emailing the corresponding author at hamoakoh@noguchi.ug.edu.gh. or h.b.amoakoh-2@umcutrecht.nl.