RT Journal Article
SR Electronic
T1 Knowledge, attitudes and practices relating to nutritional support and immune-related adverse events among patients undergoing immunotherapy for liver cancer: cross-sectional study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e086854
DO 10.1136/bmjopen-2024-086854
VO 15
IS 5
A1 Wen, Wen
A1 Chen, Yingshuang
A1 Gao, Fangqing
A1 Tong, Liling
YR 2025
UL http://bmjopen.bmj.com/content/15/5/e086854.abstract
AB Objectives To examine the knowledge, attitude and practice (KAP) regarding immune-related adverse events (irAEs) and nutritional support among patients with liver cancer (LC).Design Cross-sectional study.Setting Recruitment was carried out at Haikou People’s Hospital, Haikou, China, from December 2022 to April 2023.Participants Patients undergoing immunotherapy for LC.Primary and secondary outcome measures Mean knowledge, attitudes, practices, and lifestyle scores were assessed using an investigator-designed questionnaire completed by patients during immunotherapy.Results The study included 402 participants. The mean knowledge, attitudes, practices and lifestyle scores were 6.60±3.51 (/10, 66.00%), 41.26±5.06 (/50, 82.52%), 30.74±4.20 (/40, 76.85%) and 42.37±6.04 (/55, 77.04%), respectively. Attitude scores were associated with practice scores (β=0.381, p<0.001) and lifestyle (β=1.928, p<0.001). Urban residence was associated with higher attitude scores (β=1.242, p=0.013). Living with someone was associated with a higher attitude score (β=1.619, p=0.044). More than one immunotherapy line was associated with a higher lifestyle score (β=1.928, p<0.001). Finally, the female gender was associated with a lifestyle score (β=1.431, p=0.023).Conclusion Patients with LC and undergoing immunotherapy had moderate KAP towards irAEs and nutritional support. They also displayed moderate lifestyle scores. Urban residents, people not living alone, females and those having received two or more immunotherapy treatments were positively associated with attitude, while attitude was positively associated with practice and lifestyle.All data relevant to the study are included in the article or uploaded as supplementary information. All data generated or analysed during this study are included in this article and its supplementary materials.