RT Journal Article
SR Electronic
T1 Perioperative SARS-CoV-2 infection and postoperative complications: a single-centre retrospective cohort study in China
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e093044
DO 10.1136/bmjopen-2024-093044
VO 15
IS 5
A1 Zhan, Jia
A1 Zhong, Fei
A1 Dai, LingYan
A1 Ma, Jue
A1 Chai, YunFei
A1 Zhao, XiRui
A1 Chang, Lu
A1 Zhang, YiDan
A1 Wang, JunJiang
A1 Tang, Yong
A1 Zhong, Wen-Zhao
A1 Zhang, Guangyan
A1 Li, Le
A1 Zhu, Qiang
A1 Chen, ZhiHao
A1 Xia, Xin
A1 Peng, LiShan
A1 Wu, Jing
A1 Li, RuiYun
A1 Li, DanYang
A1 Zhu, Yan
A1 Zhou, Xin
A1 Wu, YiChun
A1 Chen, RuiRong
A1 Li, Jie
A1 Li, Yong
A1 Shu, HaiHua
YR 2025
UL http://bmjopen.bmj.com/content/15/5/e093044.abstract
AB Objective To explore the association between perioperative SARS-CoV-2 infection and the postoperative complications during the breakout of the Omicron epidemic wave.Design Observational retrospective cohort study. Multivariable logistic regression was performed to explore the association between the duration from surgery to COVID-19 diagnosis and the likelihood of postoperative complications.Setting A general hospital in China.Participants 7927 patients aged 18 years and older who underwent surgical treatment between 1 December 2022 and 28 February 2023.Primary outcome measures The outcome was a composite of postoperative adverse events that occurred within the initial 30 postoperative days.Results Of all patients, 420 (11.76%) experienced postoperative complications. Compared with No COVID-19, preoperative COVID-19 within 1 week (pre-1w) exhibited a high risk of postoperative complications (adjusted OR (aOR), 2.67; 95% CI 1.50 to 4.78), followed by patients with pre-2w (aOR, 2.14; 95% CI 1.20 to 3.80). For patients with postoperative COVID-19 within 1 week (post-1w), the aOR was 2.48 (95% CI 1.48 to 4.13), followed by patients with post-2w (aOR 1.95; 95% CI 1.10 to 3.45), and those with post-3w (aOR 2.25; 95% CI 1.27 to 3.98). The risks of postoperative complications decreased roughly with the increase of the time interval between the surgery date and SARS-CoV-2 infection. Stratification analyses suggested that perioperative COVID-19 increased the risk of postoperative complications in older patients, smokers, those with comorbidities or experiencing moderate or severe COVID-19 symptoms.Conclusions Our findings reveal a significant time-dependent relationship between perioperative COVID-19 and postoperative complications, highlighting the importance of tailored preoperative risk evaluations, enhanced postoperative surveillance, and the implementation of effective postoperative COVID-19 prevention measures.Trial registration number ChiCTR2300072473.Data are available on reasonable request.