PT  - JOURNAL ARTICLE
AU  - Zhan, Jia
AU  - Zhong, Fei
AU  - Dai, LingYan
AU  - Ma, Jue
AU  - Chai, YunFei
AU  - Zhao, XiRui
AU  - Chang, Lu
AU  - Zhang, YiDan
AU  - Wang, JunJiang
AU  - Tang, Yong
AU  - Zhong, Wen-Zhao
AU  - Zhang, Guangyan
AU  - Li, Le
AU  - Zhu, Qiang
AU  - Chen, ZhiHao
AU  - Xia, Xin
AU  - Peng, LiShan
AU  - Wu, Jing
AU  - Li, RuiYun
AU  - Li, DanYang
AU  - Zhu, Yan
AU  - Zhou, Xin
AU  - Wu, YiChun
AU  - Chen, RuiRong
AU  - Li, Jie
AU  - Li, Yong
AU  - Shu, HaiHua
TI  - Perioperative SARS-CoV-2 infection and postoperative complications: a single-centre retrospective cohort study in China
AID  - 10.1136/bmjopen-2024-093044
DP  - 2025 May 01
TA  - BMJ Open
PG  - e093044
VI  - 15
IP  - 5
4099  - http://bmjopen.bmj.com/content/15/5/e093044.short
4100  - http://bmjopen.bmj.com/content/15/5/e093044.full
SO  - BMJ Open2025 May 01; 15
AB  - Objective To explore the association between perioperative SARS-CoV-2 infection and the postoperative complications during the breakout of the Omicron epidemic wave.Design Observational retrospective cohort study. Multivariable logistic regression was performed to explore the association between the duration from surgery to COVID-19 diagnosis and the likelihood of postoperative complications.Setting A general hospital in China.Participants 7927 patients aged 18 years and older who underwent surgical treatment between 1 December 2022 and 28 February 2023.Primary outcome measures The outcome was a composite of postoperative adverse events that occurred within the initial 30 postoperative days.Results Of all patients, 420 (11.76%) experienced postoperative complications. Compared with No COVID-19, preoperative COVID-19 within 1 week (pre-1w) exhibited a high risk of postoperative complications (adjusted OR (aOR), 2.67; 95% CI 1.50 to 4.78), followed by patients with pre-2w (aOR, 2.14; 95% CI 1.20 to 3.80). For patients with postoperative COVID-19 within 1 week (post-1w), the aOR was 2.48 (95% CI 1.48 to 4.13), followed by patients with post-2w (aOR 1.95; 95% CI 1.10 to 3.45), and those with post-3w (aOR 2.25; 95% CI 1.27 to 3.98). The risks of postoperative complications decreased roughly with the increase of the time interval between the surgery date and SARS-CoV-2 infection. Stratification analyses suggested that perioperative COVID-19 increased the risk of postoperative complications in older patients, smokers, those with comorbidities or experiencing moderate or severe COVID-19 symptoms.Conclusions Our findings reveal a significant time-dependent relationship between perioperative COVID-19 and postoperative complications, highlighting the importance of tailored preoperative risk evaluations, enhanced postoperative surveillance, and the implementation of effective postoperative COVID-19 prevention measures.Trial registration number ChiCTR2300072473.Data are available on reasonable request.