RT Journal Article SR Electronic T1 Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e084999 DO 10.1136/bmjopen-2024-084999 VO 15 IS 1 A1 Miller, Amy A1 Song, Ning A1 Sivan, Manoj A1 Chowdhury, Rumana A1 Burke, Melanie Rose YR 2025 UL http://bmjopen.bmj.com/content/15/1/e084999.abstract AB Objective To explore the lived experiences and extent of cognitive symptoms in Long COVID (LC) in a UK-based sample.Design This study implemented a mixed-methods design. Eight focus groups were conducted to collect qualitative data, and the Framework Analysis was used to reveal the experiences and impact of cognitive symptoms. A self-report questionnaire was used to collect the quantitative data to assess the perceived change and extent of symptomology post COVID-19.Setting Focus groups were conducted in April 2023 online via Zoom and in-person at the University of Leeds, UK.Participants 25 people with LC living in the UK participated in the study. Participants were aged 19–76 years (M=43.6 years, SD=14.7) and included 17 women and 8 men.Results Reduced cognitive ability was among the most prevalent symptoms reported by the study participants. Three key themes were identified from the qualitative data: (1) rich accounts of cognitive symptoms; (2) the impact on physical function and psychological well-being and (3) symptom management. Descriptions of cognitive symptoms included impairments in memory, attention, language, executive function and processing speed. Cognitive symptoms had a profound impact on physical functioning and psychological well-being, including reduced ability to work and complete activities of daily living. Strategies used for symptom management varied in effectiveness.Conclusion Cognitive dysfunction in LC appears to be exacerbated by vicious cycle of withdrawal from daily life including loss of employment, physical inactivity and social isolation driving low mood, anxiety and poor cognitive functioning. Previous evidence has revealed the anatomical and physiological biomarkers in the brain affecting cognition in LC. To synthesise these contributing factors, we propose the Long-COVID Interacting Network of factors affecting Cognitive Symptoms. This framework is designed to inform clinicians and researchers to take a comprehensive approach towards LC rehabilitation, targeting the neural, individual and lifestyle factors.Data are available on reasonable request.