RT Journal Article
SR Electronic
T1 Comparison of the aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis between children and adults in southern China: a retrospective, cohort study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e085021
DO 10.1136/bmjopen-2024-085021
VO 14
IS 11
A1 Yang, Yao
A1 Lin, Jiaqi
A1 Li, Yujie
A1 Ding, Xiaohu
A1 Liu, Manli
A1 Zeng, Jieting
A1 Lin, Xiaofeng
A1 Duan, Fang
YR 2024
UL http://bmjopen.bmj.com/content/14/11/e085021.abstract
AB Objectives To compare aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis between children and adults.Design Retrospective observational study.Participants Patients admitted to Zhongshan Ophthalmic Center between January 2013 and December 2019 with clinically diagnosed endophthalmitis were included.Outcome measures The aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis were analysed.Results Of 1803 patients, 430 (23.8%) were aged ≤16 years. In both children and adults, the main aetiology was trauma (85.6% vs 64.7%, p<0.05). Streptococcus species (spp.) (28.8%) were most prevalent in paediatric post-traumatic endophthalmitis; whereas, coagulase-negative staphylococci (36.9%) were dominant in adults. In postoperative endophthalmitis, all children had bacterial infections, while fungal infections accounted for 12.5% in adults. In endogenous endophthalmitis caused by fungi, Candida was most prevalent in adults (26.9%); whereas, all causative fungi involved filamentous fungi in children. Isolated bacteria in children presented a higher susceptibility in 7 of 11 antibiotics compared with those in adults. Levofloxacin had the highest susceptibility rate in children (97.9%), and ofloxacin had the highest susceptibility rate in adults (90.6%).Conclusion The main aetiology was trauma, with a higher proportion in children than in adults. The microbial profile of paediatric endophthalmitis was different from those of adults. Susceptibilities of causative bacteria to most antibiotics were higher in children than in adults.All data relevant to the study are included in the article or uploaded as supplementary information.