RT Journal Article
SR Electronic
T1 Predicting risk factors for acute pain after hepatobiliary and pancreatic surgery: an observational case control study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e078048
DO 10.1136/bmjopen-2023-078048
VO 14
IS 8
A1 Zhang, Hui
A1 Yang, Yi Tian
A1 Jiang, Lulu
A1 Xu, Xiaodong
A1 Zhang, Jiaqiang
A1 Zhang, Lianzhong
YR 2024
UL http://bmjopen.bmj.com/content/14/8/e078048.abstract
AB Background Inadequate postoperative analgesia is associated with increased risks of various postoperative complications, longer hospital stay, decreased quality of life and higher costs.Objectives This study aimed to investigate the risk factors for moderate-to-severe postoperative pain within the first 24 hours and 24–48 hours after major hepatobiliary pancreatic surgery.Methods Data of patients who underwent surgery at the Department of Hepatobiliary Surgery in Henan Provincial People’s Hospital were collected from January 2018 to August 2020. Univariate and multivariate logistic regression analyses were used to identify the risk factors of postoperative pain.Results In total, 2180 patients were included in the final analysis. 183 patients (8.4%) suffered moderate-to-severe pain within 24 hours after operation. The independent risk factors associated with moderate-to-severe pain 24 hours after procedures were younger age (OR, 0.97; 95% CI 0.95 to 0.98, p<0.001), lower body mass index (BMI) (OR, 0.94; 95% CI 0.89 to 0.98, p=0.018), open surgery (OR, 0.34; 95% CI 0.22 to 0.52, p<0.001), and postoperative analgesia protocol with sufentanil (OR, 4.38; 95% CI 3.2 to 5.99, p<0.001). Postoperative hospital stay was longer in patients with inadequate analgesia (p<0.05).Conclusion Age, BMI, laparoscopic surgery, and different analgesic drugs were significant predictors of postoperative pain after major hepatobiliary and pancreatic surgery.Trial registration ChiCTR2100049726.Data are available upon reasonable request. The data sets used and/or analysed during the current study are available from the corresponding author on reasonable request.