RT Journal Article
SR Electronic
T1 Surveillance of antibiotics use in inpatients at Benjamin Mkapa Zonal Referral Hospital in Dodoma, Tanzania: a point prevalence survey
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e083444
DO 10.1136/bmjopen-2023-083444
VO 14
IS 8
A1 Zimbwe, Kauke Bakari
A1 Yona, Yusto Julius
A1 Chiwambo, Charity Alphonce
A1 Chandika, Alphonce Bilola
A1 Kiwelu, Humphrey Sawira
A1 Kizenga, Omary Salim
A1 Mleke, Mfaume Michael
A1 Shabani, Moshi Moshi
YR 2024
UL http://bmjopen.bmj.com/content/14/8/e083444.abstract
AB Objective To assess antibiotics prescribing and use patterns for inpatients at Benjamin Mkapa Zonal Referral Hospital (BMH) using the WHO-Point Prevalence Survey (WHO-PPS).Design A cross-sectional survey.Setting The Benjamin Mkapa Zonal Referral Hospital, Dodoma, Tanzania.Participants Inpatient prescriptions, regardless of whether antibiotics were prescribed (n=286) on the day of PPS.Outcome measures Our study analysed the prevalence of antibiotic use at BMH for inpatients, the type of antibiotics used, the indications for use and the proportion of oral and parenteral antibiotics. We also assessed prescription-prescribed antibiotics after a positive antimicrobial susceptibility testing (AST) result.Results A survey was conducted on 286 prescriptions, which revealed that 30.07% of them included antibiotics. On average, each prescription contained at least 1.6 antibiotics. All prescriptions that included antibiotics were written in generic names, and 77.91% (67/86) of them followed the Standard Treatment Guidelines. Of the prescriptions that included antibiotics, 58.14% (50/86) had a single antibiotic, 20.93% (18/86) had parenteral antibiotics and 79.07% (68/86) had oral antibiotics. Based on AWaRe’s (Access, Watch and Reserve) categorisation of antibiotics, 50% (8/16) were in the Access group, 31.25% (5/16) were in the Watch group, 12.50% (2/16) were in the Reserve group and 6.25% (1/16) were not recommended antimicrobial combinations. Out of 86 prescriptions included antibiotics, only 4.65% showed positive culture growth. However, antibiotics were still prescribed in 29.07% of prescriptions where there was no growth of bacteria, and in 66.28% of prescriptions, antibiotics were prescribed empirically without any requesting of bacteria culture and AST.Conclusion BMH has reduced inpatient Antibiotic Use by half compared with the 2019 WHO-PPS. Adherence to National Treatment Guidelines is suboptimal. Clinicians should use AST results to guide antibiotic prescribing.Data are available upon reasonable request.Data are available on reasonable request from the Benjamin Mkapa Hospital Administration. And following the National Institute for Medical Research’s policy, data can be shared upon request after signing a data transfer agreement.