PT  - JOURNAL ARTICLE
AU  - Zhang, Pei
AU  - Yang, Qilin
AU  - Yin, Chunhua
AU  - Cai, Zhigang
AU  - Lu, Huaihai
AU  - Li, Haitao
AU  - Li, Liwen
AU  - Tian, Ye
AU  - Bai, Long
AU  - Huang, Lining
TI  - Association between septic shock and tracheal injury score in intensive care unit patients with invasive ventilation: a prospective single-centre cohort study in China
AID  - 10.1136/bmjopen-2023-078763
DP  - 2024 May 01
TA  - BMJ Open
PG  - e078763
VI  - 14
IP  - 5
4099  - http://bmjopen.bmj.com/content/14/5/e078763.short
4100  - http://bmjopen.bmj.com/content/14/5/e078763.full
SO  - BMJ Open2024 May 01; 14
AB  - Objectives There was no evidence regarding the relationship between septic shock and tracheal injury scores. Investigate whether septic shock was independently associated with tracheal injury scores in intensive care unit (ICU) patients with invasive ventilation.Design Prospective observational cohort study.Setting Our study was conducted in a Class III hospital in Hebei province, China.Participants Patients over 18 years of age admitted to the ICU between 31 May 2020 and 3 May 2022 with a tracheal tube and expected to be on the tube for more than 24 hours.Primary and secondary outcome measures Tracheal injuries were evaluated by examining hyperaemia, ischaemia, ulcers and tracheal perforation by fiberoptic bronchoscope. Depending on the number of lesions, the lesions were further classified as moderate, severe or confluent.Results Among the 97 selected participants, the average age was 56.6±16.5 years, with approximately 64.9% being men. The results of adjusted linear regression showed that septic shock was associated with tracheal injury scores (β: 2.99; 95% CI 0.70 to 5.29). Subgroup analysis revealed a stronger association with a duration of intubation ≥8 days (p=0.013).Conclusion Patients with septic shock exhibit significantly higher tracheal injury scores compared with those without septic shock, suggesting that septic shock may serve as an independent risk factor for tracheal injury.Trial registration number ChiCTR2000037842, registered 03 September 2020. Retrospectively registered, https://www.chictr.org.cn/edit.aspx?pid=57011&htm=4.Data are available upon reasonable request. Data are available on reasonable request. Anonymous data sets are available from the corresponding author (27701226@hebmu.edu.cn).