RT Journal Article
SR Electronic
T1 Optimal concentration of ropivacaine for peripheral nerve blocks in adult patients: a protocol for systematic review and meta-analysis
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e077876
DO 10.1136/bmjopen-2023-077876
VO 13
IS 12
A1 Li, Jing
A1 Pan, Jiamei
A1 Xu, Ying
A1 Wang, Yi
A1 Zhang, Donghang
A1 Wei, Yiyong
YR 2023
UL http://bmjopen.bmj.com/content/13/12/e077876.abstract
AB Introduction Ropivacaine is the most widely used local anaesthetic for peripheral nerve blocks (PNBs). The effects of various concentrations of ropivacaine in PNB have been investigated and compared by many randomised controlled trials (RCTs). This protocol aims to identify the optimal concentration of ropivacaine for PNB in adult patients.Methods and analysis PubMed, EMBASE, the Cochrane library and Web of Science will be searched from their inception to 10 July 2023. RCTs that compare the analgesic effects of different concentrations of ropivacaine for PNB will be included. Retrospective studies, meta-analyses, reviews, case reports, letters, conference abstracts and paediatric studies will be excluded. The duration of analgesia will be named as the primary outcome. Secondary outcomes will include the onset time of motor and sensory blockade, postoperative pain scores, analgesic requirements over 24 hours and the incidence of adverse effects. The study selection, data extraction and quality assessment will be performed by two independent reviewers. Data processing and analysis will be performed by RevMan 5.4. The quality of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation approach.Ethics and dissemination Ethical approval is not applicable. The results of this study will be submitted to peer-reviewed journals.PROSPERO registration number CRD42023406362.