RT Journal Article
SR Electronic
T1 Oxford brain health clinic: protocol and research database
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e067808
DO 10.1136/bmjopen-2022-067808
VO 13
IS 8
A1 O'Donoghue, Melissa Clare
A1 Blane, Jasmine
A1 Gillis, Grace
A1 Mitchell, Robert
A1 Lindsay, Karen
A1 Semple, Juliet
A1 Pretorius, Pieter M
A1 Griffanti, Ludovica
A1 Fossey, Jane
A1 Raymont, Vanessa
A1 Martos, Lola
A1 Mackay, Clare E
YR 2023
UL http://bmjopen.bmj.com/content/13/8/e067808.abstract
AB Introduction Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard.Methods and analysis Here we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments.Ethics and dissemination Our ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal).