RT Journal Article
SR Electronic
T1 Dose optimisation and scarce resource allocation: two sides of the same coin
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e063436
DO 10.1136/bmjopen-2022-063436
VO 12
IS 10
A1 Strohbehn, Garth
A1 Persad, Govind
A1 Parker, William F
A1 Murthy, Srinivas
YR 2022
UL http://bmjopen.bmj.com/content/12/10/e063436.abstract
AB Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.